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000169689 0247_ $$2doi$$a10.1016/j.cell.2021.06.004
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000169689 0247_ $$2ISSN$$a1097-4172
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000169689 041__ $$aEnglish
000169689 082__ $$a610
000169689 1001_ $$aBéziat, Vivien$$b0
000169689 245__ $$aHumans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
000169689 260__ $$aNew York, NY$$bElsevier$$c2021
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000169689 520__ $$aWe study a patient with the human papilloma virus (HPV)-2-driven 'tree-man' phenotype and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2-driven multifocal benign epithelial tumor overexpressing viral oncogenes in the epidermis basal layer. The patients are unexpectedly homozygous for a private CD28 variant. They have no detectable CD28 on their T cells, with the exception of a small contingent of revertant memory CD4+ T cells. T cell development is barely affected, and T cells respond to CD3 and CD2, but not CD28, costimulation. Although the patients do not display HPV-2- and HPV-4-reactive CD4+ T cells in vitro, they make antibodies specific for both viruses in vivo. CD28-deficient mice are susceptible to cutaneous infections with the mouse papillomavirus MmuPV1. The control of HPV-2 and HPV-4 in keratinocytes is dependent on the T cell CD28 co-activation pathway. Surprisingly, human CD28-dependent T cell responses are largely redundant for protective immunity.
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000169689 650_7 $$2Other$$aCD28
000169689 650_7 $$2Other$$aHPV
000169689 650_7 $$2Other$$aT cell
000169689 650_7 $$2Other$$acutaneous horn
000169689 650_7 $$2Other$$aimmunodeficiency
000169689 650_7 $$2Other$$aoncogene
000169689 650_7 $$2Other$$apapillomavirus
000169689 650_7 $$2Other$$asomatic reversion
000169689 650_7 $$2Other$$atree man syndrome
000169689 650_7 $$2Other$$awart
000169689 7001_ $$aRapaport, Franck$$b1
000169689 7001_ $$aHu, Jiafen$$b2
000169689 7001_ $$aTiteux, Matthias$$b3
000169689 7001_ $$aBonnet des Claustres, Mathilde$$b4
000169689 7001_ $$aBourgey, Mathieu$$b5
000169689 7001_ $$aGriffin, Heather$$b6
000169689 7001_ $$aBandet, Élise$$b7
000169689 7001_ $$aMa, Cindy S$$b8
000169689 7001_ $$aSherkat, Roya$$b9
000169689 7001_ $$aRokni-Zadeh, Hassan$$b10
000169689 7001_ $$aLouis, David M$$b11
000169689 7001_ $$aChangi-Ashtiani, Majid$$b12
000169689 7001_ $$aDelmonte, Ottavia M$$b13
000169689 7001_ $$aFukushima, Toshiaki$$b14
000169689 7001_ $$aHabib, Tanwir$$b15
000169689 7001_ $$aGuennoun, Andrea$$b16
000169689 7001_ $$aKhan, Taushif$$b17
000169689 7001_ $$0P:(DE-He78)540833b33724d8def638cce2f0b4e187$$aBender, Noemi$$b18$$udkfz
000169689 7001_ $$aRahman, Mahbuba$$b19
000169689 7001_ $$aAbout, Frédégonde$$b20
000169689 7001_ $$aYang, Rui$$b21
000169689 7001_ $$aRao, Geetha$$b22
000169689 7001_ $$aRouzaud, Claire$$b23
000169689 7001_ $$aLi, Jingwei$$b24
000169689 7001_ $$aShearer, Debra$$b25
000169689 7001_ $$aBalogh, Karla$$b26
000169689 7001_ $$aAl Ali, Fatima$$b27
000169689 7001_ $$aAta, Manar$$b28
000169689 7001_ $$aDabiri, Soroosh$$b29
000169689 7001_ $$aMomenilandi, Mana$$b30
000169689 7001_ $$aNammour, Justine$$b31
000169689 7001_ $$aAlyanakian, Marie-Alexandra$$b32
000169689 7001_ $$aLeruez-Ville, Marianne$$b33
000169689 7001_ $$aGuenat, David$$b34
000169689 7001_ $$aMaterna, Marie$$b35
000169689 7001_ $$aMarcot, Léa$$b36
000169689 7001_ $$aVladikine, Natasha$$b37
000169689 7001_ $$aSoret, Christine$$b38
000169689 7001_ $$aVahidnezhad, Hassan$$b39
000169689 7001_ $$aYoussefian, Leila$$b40
000169689 7001_ $$aSaeidian, Amir Hossein$$b41
000169689 7001_ $$aUitto, Jouni$$b42
000169689 7001_ $$aCatherinot, Émilie$$b43
000169689 7001_ $$aNavabi, Shadi Sadat$$b44
000169689 7001_ $$aZarhrate, Mohammed$$b45
000169689 7001_ $$aWoodley, David T$$b46
000169689 7001_ $$aJeljeli, Mohamed$$b47
000169689 7001_ $$aAbraham, Thomas$$b48
000169689 7001_ $$aBelkaya, Serkan$$b49
000169689 7001_ $$aLorenzo, Lazaro$$b50
000169689 7001_ $$aRosain, Jérémie$$b51
000169689 7001_ $$aBayat, Mousa$$b52
000169689 7001_ $$aLanternier, Fanny$$b53
000169689 7001_ $$aLortholary, Olivier$$b54
000169689 7001_ $$aZakavi, Faramarz$$b55
000169689 7001_ $$aGros, Philippe$$b56
000169689 7001_ $$aOrth, Gérard$$b57
000169689 7001_ $$aAbel, Laurent$$b58
000169689 7001_ $$aPrétet, Jean-Luc$$b59
000169689 7001_ $$aFraitag, Sylvie$$b60
000169689 7001_ $$aJouanguy, Emmanuelle$$b61
000169689 7001_ $$aDavis, Mark M$$b62
000169689 7001_ $$aTangye, Stuart G$$b63
000169689 7001_ $$aNotarangelo, Luigi D$$b64
000169689 7001_ $$aMarr, Nico$$b65
000169689 7001_ $$0P:(DE-He78)6b4ebb9791b983b5620c0caaf3468e30$$aWaterboer, Tim$$b66$$udkfz
000169689 7001_ $$aLanglais, David$$b67
000169689 7001_ $$aDoorbar, John$$b68
000169689 7001_ $$aHovnanian, Alain$$b69
000169689 7001_ $$aChristensen, Neil$$b70
000169689 7001_ $$aBossuyt, Xavier$$b71
000169689 7001_ $$aShahrooei, Mohammad$$b72
000169689 7001_ $$aCasanova, Jean-Laurent$$b73
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