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@ARTICLE{Bziat:169689,
      author       = {V. Béziat and F. Rapaport and J. Hu and M. Titeux and M.
                      Bonnet des Claustres and M. Bourgey and H. Griffin and É.
                      Bandet and C. S. Ma and R. Sherkat and H. Rokni-Zadeh and D.
                      M. Louis and M. Changi-Ashtiani and O. M. Delmonte and T.
                      Fukushima and T. Habib and A. Guennoun and T. Khan and N.
                      Bender$^*$ and M. Rahman and F. About and R. Yang and G. Rao
                      and C. Rouzaud and J. Li and D. Shearer and K. Balogh and F.
                      Al Ali and M. Ata and S. Dabiri and M. Momenilandi and J.
                      Nammour and M.-A. Alyanakian and M. Leruez-Ville and D.
                      Guenat and M. Materna and L. Marcot and N. Vladikine and C.
                      Soret and H. Vahidnezhad and L. Youssefian and A. H.
                      Saeidian and J. Uitto and É. Catherinot and S. S. Navabi
                      and M. Zarhrate and D. T. Woodley and M. Jeljeli and T.
                      Abraham and S. Belkaya and L. Lorenzo and J. Rosain and M.
                      Bayat and F. Lanternier and O. Lortholary and F. Zakavi and
                      P. Gros and G. Orth and L. Abel and J.-L. Prétet and S.
                      Fraitag and E. Jouanguy and M. M. Davis and S. G. Tangye and
                      L. D. Notarangelo and N. Marr and T. Waterboer$^*$ and D.
                      Langlais and J. Doorbar and A. Hovnanian and N. Christensen
                      and X. Bossuyt and M. Shahrooei and J.-L. Casanova},
      title        = {{H}umans with inherited {T} cell {CD}28 deficiency are
                      susceptible to skin papillomaviruses but are otherwise
                      healthy.},
      journal      = {Cell},
      volume       = {184},
      number       = {14},
      issn         = {0092-8674},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2021-01496},
      pages        = {3812-3828.e30},
      year         = {2021},
      note         = {184(14):3812-3828.e30},
      abstract     = {We study a patient with the human papilloma virus
                      (HPV)-2-driven 'tree-man' phenotype and two relatives with
                      unusually severe HPV4-driven warts. The giant horns form an
                      HPV-2-driven multifocal benign epithelial tumor
                      overexpressing viral oncogenes in the epidermis basal layer.
                      The patients are unexpectedly homozygous for a private CD28
                      variant. They have no detectable CD28 on their T cells,
                      with the exception of a small contingent of revertant memory
                      CD4+ T cells. T cell development is barely affected, and
                      T cells respond to CD3 and CD2, but not CD28,
                      costimulation. Although the patients do not display HPV-2-
                      and HPV-4-reactive CD4+ T cells in vitro, they make
                      antibodies specific for both viruses in vivo.
                      CD28-deficient mice are susceptible to cutaneous infections
                      with the mouse papillomavirus MmuPV1. The control of HPV-2
                      and HPV-4 in keratinocytes is dependent on the T cell CD28
                      co-activation pathway. Surprisingly, human CD28-dependent
                      T cell responses are largely redundant for protective
                      immunity.},
      keywords     = {CD28 (Other) / HPV (Other) / T cell (Other) / cutaneous
                      horn (Other) / immunodeficiency (Other) / oncogene (Other) /
                      papillomavirus (Other) / somatic reversion (Other) / tree
                      man syndrome (Other) / wart (Other)},
      cin          = {F022 / F020},
      ddc          = {610},
      cid          = {I:(DE-He78)F022-20160331 / I:(DE-He78)F020-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34214472},
      doi          = {10.1016/j.cell.2021.06.004},
      url          = {https://inrepo02.dkfz.de/record/169689},
}