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| 001 | 169689 | ||
| 005 | 20240229133652.0 | ||
| 024 | 7 | _ | |a 10.1016/j.cell.2021.06.004 |2 doi |
| 024 | 7 | _ | |a pmid:34214472 |2 pmid |
| 024 | 7 | _ | |a 0092-8674 |2 ISSN |
| 024 | 7 | _ | |a 1097-4172 |2 ISSN |
| 024 | 7 | _ | |a altmetric:108511392 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2021-01496 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Béziat, Vivien |b 0 |
| 245 | _ | _ | |a Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. |
| 260 | _ | _ | |a New York, NY |c 2021 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1635318248_1489 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 184(14):3812-3828.e30 |
| 520 | _ | _ | |a We study a patient with the human papilloma virus (HPV)-2-driven 'tree-man' phenotype and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2-driven multifocal benign epithelial tumor overexpressing viral oncogenes in the epidermis basal layer. The patients are unexpectedly homozygous for a private CD28 variant. They have no detectable CD28 on their T cells, with the exception of a small contingent of revertant memory CD4+ T cells. T cell development is barely affected, and T cells respond to CD3 and CD2, but not CD28, costimulation. Although the patients do not display HPV-2- and HPV-4-reactive CD4+ T cells in vitro, they make antibodies specific for both viruses in vivo. CD28-deficient mice are susceptible to cutaneous infections with the mouse papillomavirus MmuPV1. The control of HPV-2 and HPV-4 in keratinocytes is dependent on the T cell CD28 co-activation pathway. Surprisingly, human CD28-dependent T cell responses are largely redundant for protective immunity. |
| 536 | _ | _ | |a 316 - Infektionen, Entzündung und Krebs (POF4-316) |0 G:(DE-HGF)POF4-316 |c POF4-316 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de |
| 650 | _ | 7 | |a CD28 |2 Other |
| 650 | _ | 7 | |a HPV |2 Other |
| 650 | _ | 7 | |a T cell |2 Other |
| 650 | _ | 7 | |a cutaneous horn |2 Other |
| 650 | _ | 7 | |a immunodeficiency |2 Other |
| 650 | _ | 7 | |a oncogene |2 Other |
| 650 | _ | 7 | |a papillomavirus |2 Other |
| 650 | _ | 7 | |a somatic reversion |2 Other |
| 650 | _ | 7 | |a tree man syndrome |2 Other |
| 650 | _ | 7 | |a wart |2 Other |
| 700 | 1 | _ | |a Rapaport, Franck |b 1 |
| 700 | 1 | _ | |a Hu, Jiafen |b 2 |
| 700 | 1 | _ | |a Titeux, Matthias |b 3 |
| 700 | 1 | _ | |a Bonnet des Claustres, Mathilde |b 4 |
| 700 | 1 | _ | |a Bourgey, Mathieu |b 5 |
| 700 | 1 | _ | |a Griffin, Heather |b 6 |
| 700 | 1 | _ | |a Bandet, Élise |b 7 |
| 700 | 1 | _ | |a Ma, Cindy S |b 8 |
| 700 | 1 | _ | |a Sherkat, Roya |b 9 |
| 700 | 1 | _ | |a Rokni-Zadeh, Hassan |b 10 |
| 700 | 1 | _ | |a Louis, David M |b 11 |
| 700 | 1 | _ | |a Changi-Ashtiani, Majid |b 12 |
| 700 | 1 | _ | |a Delmonte, Ottavia M |b 13 |
| 700 | 1 | _ | |a Fukushima, Toshiaki |b 14 |
| 700 | 1 | _ | |a Habib, Tanwir |b 15 |
| 700 | 1 | _ | |a Guennoun, Andrea |b 16 |
| 700 | 1 | _ | |a Khan, Taushif |b 17 |
| 700 | 1 | _ | |a Bender, Noemi |0 P:(DE-He78)540833b33724d8def638cce2f0b4e187 |b 18 |u dkfz |
| 700 | 1 | _ | |a Rahman, Mahbuba |b 19 |
| 700 | 1 | _ | |a About, Frédégonde |b 20 |
| 700 | 1 | _ | |a Yang, Rui |b 21 |
| 700 | 1 | _ | |a Rao, Geetha |b 22 |
| 700 | 1 | _ | |a Rouzaud, Claire |b 23 |
| 700 | 1 | _ | |a Li, Jingwei |b 24 |
| 700 | 1 | _ | |a Shearer, Debra |b 25 |
| 700 | 1 | _ | |a Balogh, Karla |b 26 |
| 700 | 1 | _ | |a Al Ali, Fatima |b 27 |
| 700 | 1 | _ | |a Ata, Manar |b 28 |
| 700 | 1 | _ | |a Dabiri, Soroosh |b 29 |
| 700 | 1 | _ | |a Momenilandi, Mana |b 30 |
| 700 | 1 | _ | |a Nammour, Justine |b 31 |
| 700 | 1 | _ | |a Alyanakian, Marie-Alexandra |b 32 |
| 700 | 1 | _ | |a Leruez-Ville, Marianne |b 33 |
| 700 | 1 | _ | |a Guenat, David |b 34 |
| 700 | 1 | _ | |a Materna, Marie |b 35 |
| 700 | 1 | _ | |a Marcot, Léa |b 36 |
| 700 | 1 | _ | |a Vladikine, Natasha |b 37 |
| 700 | 1 | _ | |a Soret, Christine |b 38 |
| 700 | 1 | _ | |a Vahidnezhad, Hassan |b 39 |
| 700 | 1 | _ | |a Youssefian, Leila |b 40 |
| 700 | 1 | _ | |a Saeidian, Amir Hossein |b 41 |
| 700 | 1 | _ | |a Uitto, Jouni |b 42 |
| 700 | 1 | _ | |a Catherinot, Émilie |b 43 |
| 700 | 1 | _ | |a Navabi, Shadi Sadat |b 44 |
| 700 | 1 | _ | |a Zarhrate, Mohammed |b 45 |
| 700 | 1 | _ | |a Woodley, David T |b 46 |
| 700 | 1 | _ | |a Jeljeli, Mohamed |b 47 |
| 700 | 1 | _ | |a Abraham, Thomas |b 48 |
| 700 | 1 | _ | |a Belkaya, Serkan |b 49 |
| 700 | 1 | _ | |a Lorenzo, Lazaro |b 50 |
| 700 | 1 | _ | |a Rosain, Jérémie |b 51 |
| 700 | 1 | _ | |a Bayat, Mousa |b 52 |
| 700 | 1 | _ | |a Lanternier, Fanny |b 53 |
| 700 | 1 | _ | |a Lortholary, Olivier |b 54 |
| 700 | 1 | _ | |a Zakavi, Faramarz |b 55 |
| 700 | 1 | _ | |a Gros, Philippe |b 56 |
| 700 | 1 | _ | |a Orth, Gérard |b 57 |
| 700 | 1 | _ | |a Abel, Laurent |b 58 |
| 700 | 1 | _ | |a Prétet, Jean-Luc |b 59 |
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| 700 | 1 | _ | |a Jouanguy, Emmanuelle |b 61 |
| 700 | 1 | _ | |a Davis, Mark M |b 62 |
| 700 | 1 | _ | |a Tangye, Stuart G |b 63 |
| 700 | 1 | _ | |a Notarangelo, Luigi D |b 64 |
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| 700 | 1 | _ | |a Langlais, David |b 67 |
| 700 | 1 | _ | |a Doorbar, John |b 68 |
| 700 | 1 | _ | |a Hovnanian, Alain |b 69 |
| 700 | 1 | _ | |a Christensen, Neil |b 70 |
| 700 | 1 | _ | |a Bossuyt, Xavier |b 71 |
| 700 | 1 | _ | |a Shahrooei, Mohammad |b 72 |
| 700 | 1 | _ | |a Casanova, Jean-Laurent |b 73 |
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