%0 Journal Article
%A Hibbert, Julia
%A Halec, Gordana
%A Baaken, Dan
%A Waterboer, Tim
%A Brenner, Nicole
%T Sensitivity and Specificity of Human Papillomavirus (HPV) 16 Early Antigen Serology for HPV-Driven Oropharyngeal Cancer: A Systematic Literature Review and Meta-Analysis.
%J Cancers
%V 13
%N 12
%@ 2072-6694
%C Basel
%I MDPI
%M DKFZ-2021-01504
%P 3010
%D 2021
%Z #EA:F022#LA:F022#
%X Antibodies against HPV16 early proteins have been shown to be promising biomarkers for the identification of HPV-driven oropharyngeal cancer (HPV-OPC) among OPC cases in multiple studies. A systematic literature search was performed to identify original research articles comparing HPV early antigen serology with established reference methods to determine molecular HPV tumor status. Random-effects models were used to calculate summary estimates for sensitivity and specificity of HPV16 E2, E6 and E7 serology for HPV-OPC. Subgroup analyses were performed to explore heterogeneity across studies and describe variables associated with test performance. We identified n = 23 studies meeting all eligibility criteria and included these in the meta-analysis. E6 serology showed the best performance with pooled sensitivity and specificity estimates of 83.1
%K HPV (Other)
%K antibodies (Other)
%K meta-analysis (Other)
%K oropharyngeal cancer (Other)
%K sensitivity (Other)
%K serology (Other)
%K specificity (Other)
%K systematic review (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34208476
%R 10.3390/cancers13123010
%U https://inrepo02.dkfz.de/record/169697