TY  - JOUR
AU  - Hibbert, Julia
AU  - Halec, Gordana
AU  - Baaken, Dan
AU  - Waterboer, Tim
AU  - Brenner, Nicole
TI  - Sensitivity and Specificity of Human Papillomavirus (HPV) 16 Early Antigen Serology for HPV-Driven Oropharyngeal Cancer: A Systematic Literature Review and Meta-Analysis.
JO  - Cancers
VL  - 13
IS  - 12
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2021-01504
SP  - 3010
PY  - 2021
N1  - #EA:F022#LA:F022#
AB  - Antibodies against HPV16 early proteins have been shown to be promising biomarkers for the identification of HPV-driven oropharyngeal cancer (HPV-OPC) among OPC cases in multiple studies. A systematic literature search was performed to identify original research articles comparing HPV early antigen serology with established reference methods to determine molecular HPV tumor status. Random-effects models were used to calculate summary estimates for sensitivity and specificity of HPV16 E2, E6 and E7 serology for HPV-OPC. Subgroup analyses were performed to explore heterogeneity across studies and describe variables associated with test performance. We identified n = 23 studies meeting all eligibility criteria and included these in the meta-analysis. E6 serology showed the best performance with pooled sensitivity and specificity estimates of 83.1
KW  - HPV (Other)
KW  - antibodies (Other)
KW  - meta-analysis (Other)
KW  - oropharyngeal cancer (Other)
KW  - sensitivity (Other)
KW  - serology (Other)
KW  - specificity (Other)
KW  - systematic review (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34208476
DO  - DOI:10.3390/cancers13123010
UR  - https://inrepo02.dkfz.de/record/169697
ER  -