%0 Journal Article
%A Boutin, Sébastien
%A Hildebrand, Dagmar
%A Boulant, Steeve
%A Kreuter, Michael
%A Rüter, Jule
%A Pallerla, Srinivas Reddy
%A Velavan, Thirumalaisamy P
%A Nurjadi, Dennis
%T Host factors facilitating SARS-CoV-2 virus infection and replication in the lungs.
%J Cellular and molecular life sciences
%V 78
%N 16
%@ 1420-9071
%C Cham (ZG)
%I Springer International Publishing AG
%M DKFZ-2021-01560
%P 5953-5976
%D 2021
%Z 2021 Aug;78(16):5953-5976
%X SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. However, fatal outcomes have been linked to specific host factors and co-morbidities such as age, hypertension, immuno-deficiencies, chronic lung diseases or metabolic disorders. A major shift in the microbiome of patients suffering of the coronavirus disease 2019 (COVID-19) have also been observed and is linked to a worst outcome of the disease. As many co-morbidities are already known to be associated with a dysbiosis of the microbiome such as hypertension, diabetes and metabolic disorders. Host factors and microbiome changes are believed to be involved as a network in the acquisition of the infection and the development of the diseases. We will review in detail in this manuscript, the immune response toward SARS-CoV-2 infection as well as the host factors involved in the facilitation and worsening of the infection. We will also address the impact of COVID-19 on the host's microbiome and secondary infection which also worsen the disease.
%K COVID-19 (Other)
%K Co-morbidities (Other)
%K Host factor (Other)
%K Innate immune response (Other)
%K Microbiome (Other)
%K SARS-CoV-2 (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34223911
%2 pmc:PMC8256233
%R 10.1007/s00018-021-03889-5
%U https://inrepo02.dkfz.de/record/169806