Journal Article (Review Article)

DKFZ-2021-01560

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Host factors facilitating SARS-CoV-2 virus infection and replication in the lungs.

Boutin, S. ; Hildebrand, D. ; Boulant, S.DKFZ* ; Kreuter, M. ; Rüter, J. ; Pallerla, S. R. ; Velavan, T. P. ; Nurjadi, D.

2021
Springer International Publishing AG Cham (ZG)

This record in other databases:  

Please use a persistent id in citations: doi:10.1007/s00018-021-03889-5

Abstract: SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. However, fatal outcomes have been linked to specific host factors and co-morbidities such as age, hypertension, immuno-deficiencies, chronic lung diseases or metabolic disorders. A major shift in the microbiome of patients suffering of the coronavirus disease 2019 (COVID-19) have also been observed and is linked to a worst outcome of the disease. As many co-morbidities are already known to be associated with a dysbiosis of the microbiome such as hypertension, diabetes and metabolic disorders. Host factors and microbiome changes are believed to be involved as a network in the acquisition of the infection and the development of the diseases. We will review in detail in this manuscript, the immune response toward SARS-CoV-2 infection as well as the host factors involved in the facilitation and worsening of the infection. We will also address the impact of COVID-19 on the host's microbiome and secondary infection which also worsen the disease.

Keyword(s): COVID-19 ; Co-morbidities ; Host factor ; Innate immune response ; Microbiome ; SARS-CoV-2

Note: 2021 Aug;78(16):5953-5976

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Contributing Institute(s):

1. F140 Zelluläre Polarität und virale Infektion (F140)

Research Program(s):

1. 316 - Infektionen, Entzündung und Krebs (POF4-316) (POF4-316)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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