TY  - JOUR
AU  - Boutin, Sébastien
AU  - Hildebrand, Dagmar
AU  - Boulant, Steeve
AU  - Kreuter, Michael
AU  - Rüter, Jule
AU  - Pallerla, Srinivas Reddy
AU  - Velavan, Thirumalaisamy P
AU  - Nurjadi, Dennis
TI  - Host factors facilitating SARS-CoV-2 virus infection and replication in the lungs.
JO  - Cellular and molecular life sciences
VL  - 78
IS  - 16
SN  - 1420-9071
CY  - Cham (ZG)
PB  - Springer International Publishing AG
M1  - DKFZ-2021-01560
SP  - 5953-5976
PY  - 2021
N1  - 2021 Aug;78(16):5953-5976
AB  - SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. However, fatal outcomes have been linked to specific host factors and co-morbidities such as age, hypertension, immuno-deficiencies, chronic lung diseases or metabolic disorders. A major shift in the microbiome of patients suffering of the coronavirus disease 2019 (COVID-19) have also been observed and is linked to a worst outcome of the disease. As many co-morbidities are already known to be associated with a dysbiosis of the microbiome such as hypertension, diabetes and metabolic disorders. Host factors and microbiome changes are believed to be involved as a network in the acquisition of the infection and the development of the diseases. We will review in detail in this manuscript, the immune response toward SARS-CoV-2 infection as well as the host factors involved in the facilitation and worsening of the infection. We will also address the impact of COVID-19 on the host's microbiome and secondary infection which also worsen the disease.
KW  - COVID-19 (Other)
KW  - Co-morbidities (Other)
KW  - Host factor (Other)
KW  - Innate immune response (Other)
KW  - Microbiome (Other)
KW  - SARS-CoV-2 (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34223911
C2  - pmc:PMC8256233
DO  - DOI:10.1007/s00018-021-03889-5
UR  - https://inrepo02.dkfz.de/record/169806
ER  -