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@ARTICLE{Boutin:169806,
      author       = {S. Boutin and D. Hildebrand and S. Boulant$^*$ and M.
                      Kreuter and J. Rüter and S. R. Pallerla and T. P. Velavan
                      and D. Nurjadi},
      title        = {{H}ost factors facilitating {SARS}-{C}o{V}-2 virus
                      infection and replication in the lungs.},
      journal      = {Cellular and molecular life sciences},
      volume       = {78},
      number       = {16},
      issn         = {1420-9071},
      address      = {Cham (ZG)},
      publisher    = {Springer International Publishing AG},
      reportid     = {DKFZ-2021-01560},
      pages        = {5953-5976},
      year         = {2021},
      note         = {2021 Aug;78(16):5953-5976},
      abstract     = {SARS-CoV-2 is the virus causing the major pandemic facing
                      the world today. Although, SARS-CoV-2 primarily causes lung
                      infection, a variety of symptoms have proven a systemic
                      impact on the body. SARS-CoV-2 has spread in the community
                      quickly infecting humans from all age, ethnicities and
                      gender. However, fatal outcomes have been linked to specific
                      host factors and co-morbidities such as age, hypertension,
                      immuno-deficiencies, chronic lung diseases or metabolic
                      disorders. A major shift in the microbiome of patients
                      suffering of the coronavirus disease 2019 (COVID-19) have
                      also been observed and is linked to a worst outcome of the
                      disease. As many co-morbidities are already known to be
                      associated with a dysbiosis of the microbiome such as
                      hypertension, diabetes and metabolic disorders. Host factors
                      and microbiome changes are believed to be involved as a
                      network in the acquisition of the infection and the
                      development of the diseases. We will review in detail in
                      this manuscript, the immune response toward SARS-CoV-2
                      infection as well as the host factors involved in the
                      facilitation and worsening of the infection. We will also
                      address the impact of COVID-19 on the host's microbiome and
                      secondary infection which also worsen the disease.},
      subtyp        = {Review Article},
      keywords     = {COVID-19 (Other) / Co-morbidities (Other) / Host factor
                      (Other) / Innate immune response (Other) / Microbiome
                      (Other) / SARS-CoV-2 (Other)},
      cin          = {F140},
      ddc          = {610},
      cid          = {I:(DE-He78)F140-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34223911},
      pmc          = {pmc:PMC8256233},
      doi          = {10.1007/s00018-021-03889-5},
      url          = {https://inrepo02.dkfz.de/record/169806},
}