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| 001 | 169806 | ||
| 005 | 20240229133655.0 | ||
| 024 | 7 | _ | |a 10.1007/s00018-021-03889-5 |2 doi |
| 024 | 7 | _ | |a pmid:34223911 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC8256233 |2 pmc |
| 024 | 7 | _ | |a 0014-4754 |2 ISSN |
| 024 | 7 | _ | |a 1420-682X |2 ISSN |
| 024 | 7 | _ | |a 1420-9071 |2 ISSN |
| 024 | 7 | _ | |a altmetric:108746229 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2021-01560 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Boutin, Sébastien |0 0000-0002-0499-2460 |b 0 |
| 245 | _ | _ | |a Host factors facilitating SARS-CoV-2 virus infection and replication in the lungs. |
| 260 | _ | _ | |a Cham (ZG) |c 2021 |b Springer International Publishing AG |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1642167369_15951 |2 PUB:(DE-HGF) |x Review Article |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2021 Aug;78(16):5953-5976 |
| 520 | _ | _ | |a SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. However, fatal outcomes have been linked to specific host factors and co-morbidities such as age, hypertension, immuno-deficiencies, chronic lung diseases or metabolic disorders. A major shift in the microbiome of patients suffering of the coronavirus disease 2019 (COVID-19) have also been observed and is linked to a worst outcome of the disease. As many co-morbidities are already known to be associated with a dysbiosis of the microbiome such as hypertension, diabetes and metabolic disorders. Host factors and microbiome changes are believed to be involved as a network in the acquisition of the infection and the development of the diseases. We will review in detail in this manuscript, the immune response toward SARS-CoV-2 infection as well as the host factors involved in the facilitation and worsening of the infection. We will also address the impact of COVID-19 on the host's microbiome and secondary infection which also worsen the disease. |
| 536 | _ | _ | |a 316 - Infektionen, Entzündung und Krebs (POF4-316) |0 G:(DE-HGF)POF4-316 |c POF4-316 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de |
| 650 | _ | 7 | |a COVID-19 |2 Other |
| 650 | _ | 7 | |a Co-morbidities |2 Other |
| 650 | _ | 7 | |a Host factor |2 Other |
| 650 | _ | 7 | |a Innate immune response |2 Other |
| 650 | _ | 7 | |a Microbiome |2 Other |
| 650 | _ | 7 | |a SARS-CoV-2 |2 Other |
| 700 | 1 | _ | |a Hildebrand, Dagmar |b 1 |
| 700 | 1 | _ | |a Boulant, Steeve |0 P:(DE-He78)4658b59d5b4e54b919fc63ab1213c78f |b 2 |u dkfz |
| 700 | 1 | _ | |a Kreuter, Michael |b 3 |
| 700 | 1 | _ | |a Rüter, Jule |b 4 |
| 700 | 1 | _ | |a Pallerla, Srinivas Reddy |b 5 |
| 700 | 1 | _ | |a Velavan, Thirumalaisamy P |b 6 |
| 700 | 1 | _ | |a Nurjadi, Dennis |b 7 |
| 773 | _ | _ | |a 10.1007/s00018-021-03889-5 |0 PERI:(DE-600)1458497-9 |n 16 |p 5953-5976 |t Cellular and molecular life sciences |v 78 |y 2021 |x 1420-9071 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:169806 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)4658b59d5b4e54b919fc63ab1213c78f |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-316 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Infektionen, Entzündung und Krebs |x 0 |
| 913 | 0 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-316 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Infections and cancer |x 0 |
| 914 | 1 | _ | |y 2021 |
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