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@ARTICLE{Rollison:169867,
      author       = {D. E. Rollison and R. P. Amorrortu and Y. Zhao and J. L.
                      Messina and M. J. Schell and N. A. Fenske and B. S.
                      Cherpelis and A. R. Giuliano and V. K. Sondak and M.
                      Pawlita$^*$ and S. McKay-Chopin and T. Gheit and T.
                      Waterboer$^*$ and M. Tommasino},
      title        = {{C}utaneous human papillomaviruses and the risk of
                      keratinocyte carcinomas.},
      journal      = {Cancer research},
      volume       = {81},
      number       = {17},
      issn         = {1538-7445},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2021-01601},
      pages        = {4628-4638},
      year         = {2021},
      note         = {2021 Sep 1;81(17):4628-4638},
      abstract     = {Cutaneous human papillomavirus (cuHPV) infections may be
                      novel targets for skin cancer prevention and treatment, but
                      critical information regarding the development of
                      virus-positive skin cancers following cuHPV infection has
                      been lacking. In this study, baseline cuHPV infection was
                      measured by serology and viral DNA detection in eyebrow
                      hairs (EBH) and forearm skin swabs (SSW) among 1,008
                      individuals undergoing routine skin cancer screening exams
                      and followed for incidence of basal cell carcinoma (BCC) and
                      cutaneous squamous cell carcinoma (cuSCC). Baseline beta-HPV
                      detection, particularly in SSW, significantly predicted
                      cuSCC (Hazard Ratio [HR]=4.32, $95\%$ CI=1.00-18.66),
                      whereas serologic evidence of past beta-HPV infection was
                      not associated with cuSCC. Less than $5\%$ of baseline
                      beta-HPV types detected in SSW were present in subsequent
                      cuSCC tumors, and cuHPV detected in SSW with higher mean
                      fluorescence intensity values were more likely to be present
                      in cuSCC compared to those with lower levels (p<0.001).
                      Beta-HPV-positive cuSCC occurred more often in areas of
                      highly sun-damaged skin than did beta-HPV-negative cuSCC.
                      Overall, no clear patterns were observed between baseline
                      beta-HPV detection and subsequent development of BCC, or
                      between baseline gamma-HPV detection and either cuSCC or
                      BCC. Collectively, these results demonstrate that beta-HPV
                      detection in SSW is a significant predictor of cuSCC risk,
                      although evidence suggests only a small subset of cuSCC is
                      etiologically linked to beta-HPV infection.},
      cin          = {F022 / F020},
      ddc          = {610},
      cid          = {I:(DE-He78)F022-20160331 / I:(DE-He78)F020-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34266893},
      doi          = {10.1158/0008-5472.CAN-21-0805},
      url          = {https://inrepo02.dkfz.de/record/169867},
}