Journal Article

DKFZ-2021-01601

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cutaneous human papillomaviruses and the risk of keratinocyte carcinomas.

Rollison, D. E. ; Amorrortu, R. P. ; Zhao, Y. ; Messina, J. L. ; Schell, M. J. ; Fenske, N. A. ; Cherpelis, B. S. ; Giuliano, A. R. ; Sondak, V. K. ; Pawlita, M.DKFZ* ; McKay-Chopin, S. ; Gheit, T. ; Waterboer, T.DKFZ* ; Tommasino, M.

2021
AACR Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1158/0008-5472.CAN-21-0805

Abstract: Cutaneous human papillomavirus (cuHPV) infections may be novel targets for skin cancer prevention and treatment, but critical information regarding the development of virus-positive skin cancers following cuHPV infection has been lacking. In this study, baseline cuHPV infection was measured by serology and viral DNA detection in eyebrow hairs (EBH) and forearm skin swabs (SSW) among 1,008 individuals undergoing routine skin cancer screening exams and followed for incidence of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cuSCC). Baseline beta-HPV detection, particularly in SSW, significantly predicted cuSCC (Hazard Ratio [HR]=4.32, 95% CI=1.00-18.66), whereas serologic evidence of past beta-HPV infection was not associated with cuSCC. Less than 5% of baseline beta-HPV types detected in SSW were present in subsequent cuSCC tumors, and cuHPV detected in SSW with higher mean fluorescence intensity values were more likely to be present in cuSCC compared to those with lower levels (p<0.001). Beta-HPV-positive cuSCC occurred more often in areas of highly sun-damaged skin than did beta-HPV-negative cuSCC. Overall, no clear patterns were observed between baseline beta-HPV detection and subsequent development of BCC, or between baseline gamma-HPV detection and either cuSCC or BCC. Collectively, these results demonstrate that beta-HPV detection in SSW is a significant predictor of cuSCC risk, although evidence suggests only a small subset of cuSCC is etiologically linked to beta-HPV infection.

Note: 2021 Sep 1;81(17):4628-4638

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Contributing Institute(s):

1. Infektionen und Krebs-Epidemiologie (F022)
2. Infektionen und Krebs-Epidemiologie (F020)

Research Program(s):

1. 316 - Infektionen, Entzündung und Krebs (POF4-316) (POF4-316)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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