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@ARTICLE{GaudyMarqueste:169883,
      author       = {C. Gaudy-Marqueste and N. Macagno and A. Loundou and E.
                      Pellegrino and L. Ouafik and T. Budden and P. Mundra and G.
                      Gremel and V. Akhras and L. Lin and M. Cook and R. Kumar$^*$
                      and J.-J. Grob and E. Nagore and R. Marais and A. Virós},
      title        = {{M}olecular characterization of fast-growing melanomas.},
      journal      = {Journal of the American Academy of Dermatology},
      volume       = {86},
      number       = {2},
      issn         = {0190-9622},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2021-01617},
      pages        = {312-321},
      year         = {2022},
      note         = {Volume 86, Issue 2, February 2022, Pages 312-321},
      abstract     = {The rate of growth of primary melanoma is a robust
                      predictor of aggressiveness, but the mutational profile of
                      fast-growing melanomas (FGMM), and its potential to stratify
                      patients at high risk of death, has not been comprehensively
                      studied.To investigate the epidemiological, clinical and
                      mutational profile of primary cutaneous melanomas with a
                      thickness ≥ 1mm, stratified by rate of growth
                      (ROG).Observational prospective study. Deep-targeted
                      sequencing of 40 melanoma driver genes on formalin fixed,
                      paraffin embedded primary melanoma samples. Comparison of
                      FGMM (ROG >0.5mm/month) and non-FGMM (ROG≤0.5
                      mm/month).Two hundred patients were enrolled among which 70
                      were FGMM. The relapse free survival was lower in the FGMM
                      group (p=0.014). FGMM had a higher number of predicted
                      deleterious mutations within the 40 genes than non-FGMM
                      (p=0.033). Ulceration (p=0.032), thickness (p=0.006), lower
                      sun exposure (p=0.049), and FGFR2 mutations (p=0.037) were
                      significantly associated with fast growth.Single-center
                      study, cohort size, potential memory bias, number of
                      investigated genes.Fast growth is linked to specific tumor
                      biology and environmental factors. Ulceration, thickness and
                      FGFR2 mutations associate with fast growth. Screening for
                      FGFR2 mutations might provide an additional tool to better
                      identify FGMM which are probably good candidates for
                      adjuvant therapies.},
      keywords     = {FGFR2 mutations (Other) / Melanoma (Other) / fast growth
                      melanoma (Other) / mutations of poor prognosis (Other)},
      cin          = {B070},
      ddc          = {610},
      cid          = {I:(DE-He78)B070-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34280484},
      doi          = {10.1016/j.jaad.2021.07.011},
      url          = {https://inrepo02.dkfz.de/record/169883},
}