Journal Article

DKFZ-2021-01617

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Molecular characterization of fast-growing melanomas.

Gaudy-Marqueste, C. ; Macagno, N. ; Loundou, A. ; Pellegrino, E. ; Ouafik, L. ; Budden, T. ; Mundra, P. ; Gremel, G. ; Akhras, V. ; Lin, L. ; Cook, M. ; Kumar, R.DKFZ* ; Grob, J.-J. ; Nagore, E. ; Marais, R. ; Virós, A.

2022
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.jaad.2021.07.011

Abstract: The rate of growth of primary melanoma is a robust predictor of aggressiveness, but the mutational profile of fast-growing melanomas (FGMM), and its potential to stratify patients at high risk of death, has not been comprehensively studied.To investigate the epidemiological, clinical and mutational profile of primary cutaneous melanomas with a thickness ≥ 1mm, stratified by rate of growth (ROG).Observational prospective study. Deep-targeted sequencing of 40 melanoma driver genes on formalin fixed, paraffin embedded primary melanoma samples. Comparison of FGMM (ROG >0.5mm/month) and non-FGMM (ROG≤0.5 mm/month).Two hundred patients were enrolled among which 70 were FGMM. The relapse free survival was lower in the FGMM group (p=0.014). FGMM had a higher number of predicted deleterious mutations within the 40 genes than non-FGMM (p=0.033). Ulceration (p=0.032), thickness (p=0.006), lower sun exposure (p=0.049), and FGFR2 mutations (p=0.037) were significantly associated with fast growth.Single-center study, cohort size, potential memory bias, number of investigated genes.Fast growth is linked to specific tumor biology and environmental factors. Ulceration, thickness and FGFR2 mutations associate with fast growth. Screening for FGFR2 mutations might provide an additional tool to better identify FGMM which are probably good candidates for adjuvant therapies.

Keyword(s): FGFR2 mutations ; Melanoma ; fast growth melanoma ; mutations of poor prognosis

Note: Volume 86, Issue 2, February 2022, Pages 312-321

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Contributing Institute(s):

1. B070 Funktionelle Genomanalyse (B070)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2021

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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