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| 001 | 169948 | ||
| 005 | 20251113161413.0 | ||
| 024 | 7 | _ | |a 10.1016/j.stemcr.2021.06.013 |2 doi |
| 024 | 7 | _ | |a pmid:34297939 |2 pmid |
| 024 | 7 | _ | |a altmetric:110548011 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2021-01648 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Bujanover, Nir |b 0 |
| 245 | _ | _ | |a Hypersensitivity response has negligible impact on Hematopoietic Stem Cells. |
| 260 | _ | _ | |a [New York, NY] |c 2021 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1763046840_4080001 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a DKFZ-ZMBH Alliance / 2021 Aug 10;16(8):1884-1893 / #DKFZ-MOST-Ca179# |
| 520 | _ | _ | |a Immune cells are generated from hematopoietic stem cells (HSCs) in the bone marrow (BM). Immune stimulation can rapidly activate HSCs out of their quiescent state to accelerate the generation of immune cells. HSCs' activation follows various viral or bacterial stimuli, and we sought to investigate the hypersensitivity immune response. Surprisingly, the Ova-induced hypersensitivity peritonitis model finds no significant changes in BM HSCs. HSC markers cKIT, SCA1, CD48, CD150, and the Fgd5-mCherry reporter showed no significant difference from control. Functionally, hypersensitivity did not alter HSCs' potency, as assayed by transplantation. We further characterized the possible impact of hypersensitivity using RNA-sequencing of HSCs, finding minor changes at the transcriptome level. Moreover, hypersensitivity induced no significant change in the proliferative state of HSCs. Therefore, this study suggests that, in contrast to other immune stimuli, hypersensitivity has no impact on HSCs. |
| 536 | _ | _ | |a 311 - Zellbiologie und Tumorbiologie (POF4-311) |0 G:(DE-HGF)POF4-311 |c POF4-311 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de |
| 650 | _ | 7 | |a dormancy |2 Other |
| 650 | _ | 7 | |a hematopoietic stem cells |2 Other |
| 650 | _ | 7 | |a hypersensitivity |2 Other |
| 650 | _ | 7 | |a immune response |2 Other |
| 650 | _ | 7 | |a quiescence |2 Other |
| 700 | 1 | _ | |a Thapa, Roshina |b 1 |
| 700 | 1 | _ | |a Goldstein, Oron |b 2 |
| 700 | 1 | _ | |a Olender, Leonid |b 3 |
| 700 | 1 | _ | |a Sharabi, Omri |b 4 |
| 700 | 1 | _ | |a Milsom, Michael D |0 P:(DE-He78)7b613cadb8c16ce178713e15b85d982c |b 5 |u dkfz |
| 700 | 1 | _ | |a Gazit, Roi |b 6 |
| 773 | _ | _ | |a 10.1016/j.stemcr.2021.06.013 |g p. S2213671121003210 |0 PERI:(DE-600)2720528-9 |n 8 |p 1884-1893 |t Stem cell reports |v 16 |y 2021 |x 2213-6711 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:169948 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 5 |6 P:(DE-He78)7b613cadb8c16ce178713e15b85d982c |
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| 914 | 1 | _ | |y 2021 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b STEM CELL REP : 2019 |d 2021-02-03 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2021-02-03 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2021-02-03 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |d 2021-02-03 |
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