Journal Article

DKFZ-2021-01648

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Hypersensitivity response has negligible impact on Hematopoietic Stem Cells.

Bujanover, N. ; Thapa, R. ; Goldstein, O. ; Olender, L. ; Sharabi, O. ; Milsom, M. D.DKFZ* ; Gazit, R.

2021
Elsevier [New York, NY]

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Please use a persistent id in citations: doi:10.1016/j.stemcr.2021.06.013

Abstract: Immune cells are generated from hematopoietic stem cells (HSCs) in the bone marrow (BM). Immune stimulation can rapidly activate HSCs out of their quiescent state to accelerate the generation of immune cells. HSCs' activation follows various viral or bacterial stimuli, and we sought to investigate the hypersensitivity immune response. Surprisingly, the Ova-induced hypersensitivity peritonitis model finds no significant changes in BM HSCs. HSC markers cKIT, SCA1, CD48, CD150, and the Fgd5-mCherry reporter showed no significant difference from control. Functionally, hypersensitivity did not alter HSCs' potency, as assayed by transplantation. We further characterized the possible impact of hypersensitivity using RNA-sequencing of HSCs, finding minor changes at the transcriptome level. Moreover, hypersensitivity induced no significant change in the proliferative state of HSCs. Therefore, this study suggests that, in contrast to other immune stimuli, hypersensitivity has no impact on HSCs.

Keyword(s): dormancy ; hematopoietic stem cells ; hypersensitivity ; immune response ; quiescence

Note: DKFZ-ZMBH Alliance / 2021 Aug 10;16(8):1884-1893 / #DKFZ-MOST-Ca179#

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Contributing Institute(s):

1. Experimentelle Hämatologie (A012)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2021

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