%0 Journal Article
%A Raut, Janhavi
%A Schöttker, Ben
%A Holleczek, Bernd
%A Guo, Feng
%A Bhardwaj, Megha
%A Miah, Kaya
%A Schrotz-King, Petra
%A Brenner, Hermann
%T A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction.
%J Nature Communications
%V 12
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DKFZ-2021-01818
%P 4811
%D 2021
%Z #EA:C120#LA:C070#
%X Circulating microRNAs (miRNAs) could improve colorectal cancer (CRC) risk prediction. Here, we derive a blood-based miRNA panel and evaluate its ability to predict CRC occurrence in a population-based cohort of adults aged 50-75 years. Forty-one miRNAs are preselected from independent studies and measured by quantitative-real-time-polymerase-chain-reaction in serum collected at baseline of 198 participants who develop CRC during 14 years of follow-up and 178 randomly selected controls. A 7-miRNA score is derived by logistic regression. Its predictive ability, quantified by the optimism-corrected area-under-the-receiver-operating-characteristic-curve (AUC) using .632+ bootstrap is 0.794. Predictive ability is compared to that of an environmental risk score (ERS) based on known risk factors and a polygenic risk score (PRS) based on 140 previously identified single-nucleotide-polymorphisms. In participants with all scores available, optimism-corrected-AUC is 0.802 for the 7-miRNA score, while AUC (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34376648
%R 10.1038/s41467-021-25067-8
%U https://inrepo02.dkfz.de/record/170195