Journal Article

DKFZ-2021-01818

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction.

Raut, J. (First author)DKFZ* ; Schöttker, B.DKFZ* ; Holleczek, B. ; Guo, F.DKFZ* ; Bhardwaj, M.DKFZ* ; Miah, K.DKFZ* ; Schrotz-King, P.DKFZ* ; Brenner, H. (Last author)DKFZ*

2021
Nature Publishing Group UK [London]

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Please use a persistent id in citations: doi:10.1038/s41467-021-25067-8

Abstract: Circulating microRNAs (miRNAs) could improve colorectal cancer (CRC) risk prediction. Here, we derive a blood-based miRNA panel and evaluate its ability to predict CRC occurrence in a population-based cohort of adults aged 50-75 years. Forty-one miRNAs are preselected from independent studies and measured by quantitative-real-time-polymerase-chain-reaction in serum collected at baseline of 198 participants who develop CRC during 14 years of follow-up and 178 randomly selected controls. A 7-miRNA score is derived by logistic regression. Its predictive ability, quantified by the optimism-corrected area-under-the-receiver-operating-characteristic-curve (AUC) using .632+ bootstrap is 0.794. Predictive ability is compared to that of an environmental risk score (ERS) based on known risk factors and a polygenic risk score (PRS) based on 140 previously identified single-nucleotide-polymorphisms. In participants with all scores available, optimism-corrected-AUC is 0.802 for the 7-miRNA score, while AUC (95% CI) is 0.557 (0.498-0.616) for the ERS and 0.622 (0.564-0.681) for the PRS.

Note: #EA:C120#LA:C070#

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Contributing Institute(s):

1. Präventive Onkologie (C120)
2. C070 Klinische Epidemiologie und Alternf. (C070)
3. DKTK HD zentral (HD01)
4. C060 Biostatistik (C060)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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