TY  - JOUR
AU  - Raut, Janhavi
AU  - Schöttker, Ben
AU  - Holleczek, Bernd
AU  - Guo, Feng
AU  - Bhardwaj, Megha
AU  - Miah, Kaya
AU  - Schrotz-King, Petra
AU  - Brenner, Hermann
TI  - A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction.
JO  - Nature Communications
VL  - 12
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - DKFZ-2021-01818
SP  - 4811
PY  - 2021
N1  - #EA:C120#LA:C070#
AB  - Circulating microRNAs (miRNAs) could improve colorectal cancer (CRC) risk prediction. Here, we derive a blood-based miRNA panel and evaluate its ability to predict CRC occurrence in a population-based cohort of adults aged 50-75 years. Forty-one miRNAs are preselected from independent studies and measured by quantitative-real-time-polymerase-chain-reaction in serum collected at baseline of 198 participants who develop CRC during 14 years of follow-up and 178 randomly selected controls. A 7-miRNA score is derived by logistic regression. Its predictive ability, quantified by the optimism-corrected area-under-the-receiver-operating-characteristic-curve (AUC) using .632+ bootstrap is 0.794. Predictive ability is compared to that of an environmental risk score (ERS) based on known risk factors and a polygenic risk score (PRS) based on 140 previously identified single-nucleotide-polymorphisms. In participants with all scores available, optimism-corrected-AUC is 0.802 for the 7-miRNA score, while AUC (95
LB  - PUB:(DE-HGF)16
C6  - pmid:34376648
DO  - DOI:10.1038/s41467-021-25067-8
UR  - https://inrepo02.dkfz.de/record/170195
ER  -