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@ARTICLE{Raut:170195,
      author       = {J. Raut$^*$ and B. Schöttker$^*$ and B. Holleczek and F.
                      Guo$^*$ and M. Bhardwaj$^*$ and K. Miah$^*$ and P.
                      Schrotz-King$^*$ and H. Brenner$^*$},
      title        = {{A} micro{RNA} panel compared to environmental and
                      polygenic scores for colorectal cancer risk prediction.},
      journal      = {Nature Communications},
      volume       = {12},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2021-01818},
      pages        = {4811},
      year         = {2021},
      note         = {#EA:C120#LA:C070#},
      abstract     = {Circulating microRNAs (miRNAs) could improve colorectal
                      cancer (CRC) risk prediction. Here, we derive a blood-based
                      miRNA panel and evaluate its ability to predict CRC
                      occurrence in a population-based cohort of adults aged 50-75
                      years. Forty-one miRNAs are preselected from independent
                      studies and measured by
                      quantitative-real-time-polymerase-chain-reaction in serum
                      collected at baseline of 198 participants who develop CRC
                      during 14 years of follow-up and 178 randomly selected
                      controls. A 7-miRNA score is derived by logistic regression.
                      Its predictive ability, quantified by the optimism-corrected
                      area-under-the-receiver-operating-characteristic-curve (AUC)
                      using .632+ bootstrap is 0.794. Predictive ability is
                      compared to that of an environmental risk score (ERS) based
                      on known risk factors and a polygenic risk score (PRS) based
                      on 140 previously identified
                      single-nucleotide-polymorphisms. In participants with all
                      scores available, optimism-corrected-AUC is 0.802 for the
                      7-miRNA score, while AUC $(95\%$ CI) is 0.557 (0.498-0.616)
                      for the ERS and 0.622 (0.564-0.681) for the PRS.},
      cin          = {C120 / C070 / HD01 / C060},
      ddc          = {500},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34376648},
      doi          = {10.1038/s41467-021-25067-8},
      url          = {https://inrepo02.dkfz.de/record/170195},
}