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000170294 0247_ $$2doi$$a10.1016/j.celrep.2021.109522
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000170294 1001_ $$aLuck, Robert$$b0
000170294 245__ $$aThe angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner.
000170294 260__ $$a[New York, NY]$$bElsevier$$c2021
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000170294 520__ $$aNeuro-vascular communication is essential to synchronize central nervous system development. Here, we identify angiopoietin/Tie2 as a neuro-vascular signaling axis involved in regulating dendritic morphogenesis of Purkinje cells (PCs). We show that in the developing cerebellum Tie2 expression is not restricted to blood vessels, but it is also present in PCs. Its ligands angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) are expressed in neural cells and endothelial cells (ECs), respectively. PC-specific deletion of Tie2 results in reduced dendritic arborization, which is recapitulated in neural-specific Ang1-knockout and Ang2 full-knockout mice. Mechanistically, RNA sequencing reveals that Tie2-deficient PCs present alterations in gene expression of multiple genes involved in cytoskeleton organization, dendritic formation, growth, and branching. Functionally, mice with deletion of Tie2 in PCs present alterations in PC network functionality. Altogether, our data propose Ang/Tie2 signaling as a mediator of intercellular communication between neural cells, ECs, and PCs, required for proper PC dendritic morphogenesis and function.
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000170294 650_7 $$2Other$$aPurkinje cell
000170294 650_7 $$2Other$$aTie2
000170294 650_7 $$2Other$$aangiogenesis
000170294 650_7 $$2Other$$aangipoietin
000170294 650_7 $$2Other$$ablood vessels
000170294 650_7 $$2Other$$acerebellum
000170294 650_7 $$2Other$$adendritic branching
000170294 650_7 $$2Other$$adendritic morphology
000170294 650_7 $$2Other$$aneuro-vascular
000170294 650_7 $$2Other$$aneurodevelopment
000170294 7001_ $$aKarakatsani, Andromachi$$b1
000170294 7001_ $$aShah, Bhavin$$b2
000170294 7001_ $$aSchermann, Geza$$b3
000170294 7001_ $$aAdler, Heike$$b4
000170294 7001_ $$aKupke, Janina$$b5
000170294 7001_ $$aTisch, Nathalie$$b6
000170294 7001_ $$aJeong, Hyun-Woo$$b7
000170294 7001_ $$aBack, Michaela Kerstin$$b8
000170294 7001_ $$aHetsch, Florian$$b9
000170294 7001_ $$aD'Errico, Anna$$b10
000170294 7001_ $$aDe Palma, Michele$$b11
000170294 7001_ $$aWiedtke, Ellen$$b12
000170294 7001_ $$aGrimm, Dirk$$b13
000170294 7001_ $$aAcker-Palmer, Amparo$$b14
000170294 7001_ $$avon Engelhardt, Jakob$$b15
000170294 7001_ $$aAdams, Ralf H$$b16
000170294 7001_ $$0P:(DE-He78)2e92d0ae281932fc7347d819fec36b0b$$aAugustin, Hellmut G$$b17$$udkfz
000170294 7001_ $$aRuiz de Almodóvar, Carmen$$b18
000170294 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2021.109522$$gVol. 36, no. 7, p. 109522 -$$n7$$p109522$$tCell reports$$v36$$x2211-1247$$y2021
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