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000170447 1001_ $$00000-0002-2242-0562$$aSarropoulos, Ioannis$$b0
000170447 245__ $$aDevelopmental and evolutionary dynamics of cis-regulatory elements in mouse cerebellar cells.
000170447 260__ $$aCambridge, Mass.$$bMoses King$$c2021
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000170447 520__ $$aOrgan development is orchestrated by cell- and time-specific gene regulatory networks. In this study, we investigated the regulatory basis of mouse cerebellum development from early neurogenesis to adulthood. By acquiring snATAC-seq (single-nucleus assay for transposase accessible chromatin using sequencing) profiles for ~90,000 cells spanning 11 stages, we mapped cerebellar cell types and identified candidate cis-regulatory elements (CREs). We detected extensive spatiotemporal heterogeneity among progenitor cells and a gradual divergence in the regulatory programs of cerebellar neurons during differentiation. Comparisons to vertebrate genomes and snATAC-seq profiles for ∼20,000 cerebellar cells from the marsupial opossum revealed a shared decrease in CRE conservation during development and differentiation as well as differences in constraint between cell types. Our work delineates the developmental and evolutionary dynamics of gene regulation in cerebellar cells and provides insights into mammalian organ development.
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000170447 7001_ $$00000-0003-1733-8385$$aSepp, Mari$$b1
000170447 7001_ $$00000-0002-0438-8677$$aFrömel, Robert$$b2
000170447 7001_ $$00000-0002-5955-6076$$aLeiss, Kevin$$b3
000170447 7001_ $$00000-0002-5171-018X$$aTrost, Nils$$b4
000170447 7001_ $$aLeushkin, Evgeny$$b5
000170447 7001_ $$0P:(DE-He78)34b3639de467b2c700920d7cbc3d2110$$aOkonechnikov, Konstantin$$b6$$udkfz
000170447 7001_ $$0P:(DE-He78)ee036c22158d4b18f5228616af640355$$aJoshi, Piyush Kumar$$b7$$udkfz
000170447 7001_ $$00000-0002-5570-0085$$aGiere, Peter$$b8
000170447 7001_ $$0P:(DE-He78)a56d7a8e916d458441b5ac9484d73c5d$$aKutscher, Lena$$b9$$udkfz
000170447 7001_ $$00000-0001-6639-3597$$aCardoso-Moreira, Margarida$$b10
000170447 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b11$$eLast author$$udkfz
000170447 7001_ $$00000-0001-7563-839X$$aKaessmann, Henrik$$b12
000170447 773__ $$0PERI:(DE-600)2066996-3$$a10.1126/science.abg4696$$gVol. 373, no. 6558, p. eabg4696 -$$n6558$$peabg4696 -$$tScience$$v373$$x0036-8075$$y2021
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