% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Sarropoulos:170447,
      author       = {I. Sarropoulos and M. Sepp and R. Frömel and K. Leiss and
                      N. Trost and E. Leushkin and K. Okonechnikov$^*$ and P. K.
                      Joshi$^*$ and P. Giere and L. Kutscher$^*$ and M.
                      Cardoso-Moreira and S. Pfister$^*$ and H. Kaessmann},
      title        = {{D}evelopmental and evolutionary dynamics of cis-regulatory
                      elements in mouse cerebellar cells.},
      journal      = {Science},
      volume       = {373},
      number       = {6558},
      issn         = {0036-8075},
      address      = {Cambridge, Mass.},
      publisher    = {Moses King},
      reportid     = {DKFZ-2021-01940},
      pages        = {eabg4696 -},
      year         = {2021},
      note         = {#LA:B062#},
      abstract     = {Organ development is orchestrated by cell- and
                      time-specific gene regulatory networks. In this study, we
                      investigated the regulatory basis of mouse cerebellum
                      development from early neurogenesis to adulthood. By
                      acquiring snATAC-seq (single-nucleus assay for transposase
                      accessible chromatin using sequencing) profiles for ~90,000
                      cells spanning 11 stages, we mapped cerebellar cell types
                      and identified candidate cis-regulatory elements (CREs). We
                      detected extensive spatiotemporal heterogeneity among
                      progenitor cells and a gradual divergence in the regulatory
                      programs of cerebellar neurons during differentiation.
                      Comparisons to vertebrate genomes and snATAC-seq profiles
                      for ∼20,000 cerebellar cells from the marsupial opossum
                      revealed a shared decrease in CRE conservation during
                      development and differentiation as well as differences in
                      constraint between cell types. Our work delineates the
                      developmental and evolutionary dynamics of gene regulation
                      in cerebellar cells and provides insights into mammalian
                      organ development.},
      cin          = {B062 / HD01 / B430},
      ddc          = {500},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B430-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34446581},
      doi          = {10.1126/science.abg4696},
      url          = {https://inrepo02.dkfz.de/record/170447},
}