| Home > Publications database > Quality of life after simultaneously integrated boost with intensity-modulated versus conventional radiotherapy with sequential boost for adjuvant treatment of breast cancer: 2-year results of the multicenter randomized IMRT-MC2 trial. |
| Journal Article | DKFZ-2021-01983 |
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2021
Elsevier Science
Amsterdam [u.a.]
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Please use a persistent id in citations: doi:10.1016/j.radonc.2021.08.019
Abstract: We recently published 2-year results of the prospective, randomized IMRT-MC2 trial, showing non-inferior local control and cosmesis in breast cancer patients after conventionally fractionated intensity-modulated radiotherapy with simultaneously integrated boost (IMRT-SIB), compared to 3D-conformal radiotherapy with sequential boost (3D-CRT-seqB). Here, we report on 2-year quality of life results.502 patients were enrolled and randomized to IMRT-SIB (50.4 Gy in 1.8 Gy fractions with a 64.4 Gy SIB to the tumor bed) or to 3D-CRT-seqB (50.4 Gy in 1.8 Gy fractions, followed by a sequential boost of 16 Gy in 2 Gy fractions). For quality of life (QoL) assessment, patients completed the QLQ-C30 and QLQ-BR23 questionnaires at baseline, 6 weeks and 2 years after radiotherapy.Significant differences between treatment arms were seen 6 weeks after radiotherapy for pain (22.3 points for IMRT vs. 27.0 points for 3D-CRT-seqB; p = 0.033) and arm symptoms (18.1 points for IMRT vs. 23.6 points for 3D-CRT-seqB; p = 0.013;), both favoring IMRT-SIB. Compared to baseline values, both arms showed significant improvement in global score (IMRT: p=0.009; 3D-CRT: p=0.001,) after 2 years, with slight deterioration on the role (IMRT: p=0.008; 3-D-CRT: p=0.001,) and social functioning (IMRT: p=0.013, 3D-CRT: p=0.001) as well as the future perspectives scale (IMRT: p=0.003; 3D-CRT: p=0.0034).This is the first randomized phase III trial demonstrating that IMRT-SIB was associated with slightly superior QoL compared to 3-D-CRT-seqB. These findings further support the clinical implementation of SIB in adjuvant breast cancer treatment.
Keyword(s): 3-D-conformal radiotherapy ; Breast cancer ; intensity-modulated radiotherapy (IMRT) ; quality of life ; sequential boost irradiation ; simultaneously integrated boost (SIB)
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