%0 Journal Article
%A Deng, Maximilian Yuanzhe
%A Sturm, Dominik
%A Pfaff, Elke
%A Sill, Martin
%A Stichel, Damian
%A Balasubramanian, Gnana Prakash
%A Tippelt, Stephan
%A Kramm, Christof
%A Donson, Andrew M
%A Green, Adam L
%A Jones, Chris
%A Schittenhelm, Jens
%A Ebinger, Martin
%A Schuhmann, Martin U
%A Jones, Barbara C
%A van Tilburg, Cornelis M
%A Wittmann, Andrea
%A Golanov, Andrey
%A Ryzhova, Marina
%A Ecker, Jonas
%A Milde, Till
%A Witt, Olaf
%A Sahm, Felix
%A Reuss, David
%A Sumerauer, David
%A Zamecnik, Josef
%A Korshunov, Andrey
%A von Deimling, Andreas
%A Pfister, Stefan M
%A Jones, David
%T Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B.
%J Nature Communications
%V 12
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DKFZ-2021-02126
%P 5530
%D 2021
%Z #EA:B360#LA:B360#
%X Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n = 23) and ALL (n = 9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2, uncovering diagnostic markers and potentially actionable targets.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34545083
%2 pmc:PMC8452680
%R 10.1038/s41467-021-25708-y
%U https://inrepo02.dkfz.de/record/176884