Journal Article

DKFZ-2021-02126

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B.

Deng, M. Y. (First author)DKFZ* ; Sturm, D. (First author)DKFZ* ; Pfaff, E. (First author)DKFZ* ; Sill, M.DKFZ* ; Stichel, D.DKFZ* ; Balasubramanian, G. P.DKFZ* ; Tippelt, S. ; Kramm, C. ; Donson, A. M. ; Green, A. L. ; Jones, C. ; Schittenhelm, J. ; Ebinger, M. ; Schuhmann, M. U. ; Jones, B. C.DKFZ* ; van Tilburg, C. M.DKFZ* ; Wittmann, A.DKFZ* ; Golanov, A. ; Ryzhova, M. ; Ecker, J.DKFZ* ; Milde, T.DKFZ* ; Witt, O.DKFZ* ; Sahm, F.DKFZ* ; Reuss, D.DKFZ* ; Sumerauer, D. ; Zamecnik, J. ; Korshunov, A.DKFZ* ; von Deimling, A.DKFZ* ; Pfister, S. M.DKFZ* ; Jones, D. (Last author)DKFZ*

2021
Nature Publishing Group UK [London]

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Please use a persistent id in citations: doi:10.1038/s41467-021-25708-y

Abstract: Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n = 23) and ALL (n = 9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2, uncovering diagnostic markers and potentially actionable targets.

Note: #EA:B360#LA:B360#

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Contributing Institute(s):

1. Pediatric Glioma (B360)
2. B062 Pädiatrische Neuroonkologie (B062)
3. DKTK HD zentral (HD01)
4. KKE Neuropathologie (B300)
5. KKE Pädiatrische Onkologie (B310)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2021

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