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000176884 1001_ $$0P:(DE-He78)ce7d0cd1f5edc5c0e08c39b3fdd7b410$$aDeng, Maximilian Yuanzhe$$b0$$eFirst author$$udkfz
000176884 245__ $$aRadiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B.
000176884 260__ $$a[London]$$bNature Publishing Group UK$$c2021
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000176884 520__ $$aLong-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n = 23) and ALL (n = 9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2, uncovering diagnostic markers and potentially actionable targets.
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000176884 7001_ $$0P:(DE-He78)a46a5b2a871859c8e2d63d2f8c666807$$aSturm, Dominik$$b1$$eFirst author$$udkfz
000176884 7001_ $$0P:(DE-He78)c0538fae462bd98e3cd8d54ed885b0eb$$aPfaff, Elke$$b2$$eFirst author$$udkfz
000176884 7001_ $$0P:(DE-He78)45440b44791309bd4b7dbb4f73333f9b$$aSill, Martin$$b3$$udkfz
000176884 7001_ $$0P:(DE-He78)d20d08adc992abdb6ccffa1686f1ba17$$aStichel, Damian$$b4$$udkfz
000176884 7001_ $$0P:(DE-He78)e5bb26ffbde307745ae396c2e829dac5$$aBalasubramanian, Gnana Prakash$$b5$$udkfz
000176884 7001_ $$aTippelt, Stephan$$b6
000176884 7001_ $$aKramm, Christof$$b7
000176884 7001_ $$aDonson, Andrew M$$b8
000176884 7001_ $$00000-0002-4469-2358$$aGreen, Adam L$$b9
000176884 7001_ $$aJones, Chris$$b10
000176884 7001_ $$00000-0002-9168-6209$$aSchittenhelm, Jens$$b11
000176884 7001_ $$00000-0002-4229-8058$$aEbinger, Martin$$b12
000176884 7001_ $$aSchuhmann, Martin U$$b13
000176884 7001_ $$0P:(DE-He78)fae1bf941c5fd76cf5356ecfa1243cc4$$aJones, Barbara C$$b14$$udkfz
000176884 7001_ $$0P:(DE-He78)a6b5fcabf661bef95109dbee87dc5271$$avan Tilburg, Cornelis M$$b15$$udkfz
000176884 7001_ $$0P:(DE-He78)adf0bc22f6c87d09ddb939645a7870ed$$aWittmann, Andrea$$b16$$udkfz
000176884 7001_ $$aGolanov, Andrey$$b17
000176884 7001_ $$aRyzhova, Marina$$b18
000176884 7001_ $$0P:(DE-He78)3de637452ba900e2bdd359b8f41953bf$$aEcker, Jonas$$b19$$udkfz
000176884 7001_ $$0P:(DE-He78)0be2f86573954f87e97f8a4dbb05cb0f$$aMilde, Till$$b20$$udkfz
000176884 7001_ $$0P:(DE-He78)143af26de9d57bf624771616318aaf7c$$aWitt, Olaf$$b21$$udkfz
000176884 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b22$$udkfz
000176884 7001_ $$0P:(DE-He78)d5149ffd74f42a2fa87a086d66645aaa$$aReuss, David$$b23$$udkfz
000176884 7001_ $$aSumerauer, David$$b24
000176884 7001_ $$aZamecnik, Josef$$b25
000176884 7001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b26$$udkfz
000176884 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b27$$udkfz
000176884 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b28$$udkfz
000176884 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b29$$eLast author$$udkfz
000176884 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-021-25708-y$$gVol. 12, no. 1, p. 5530$$n1$$p5530$$tNature Communications$$v12$$x2041-1723$$y2021
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