TY  - JOUR
AU  - Deng, Maximilian Yuanzhe
AU  - Sturm, Dominik
AU  - Pfaff, Elke
AU  - Sill, Martin
AU  - Stichel, Damian
AU  - Balasubramanian, Gnana Prakash
AU  - Tippelt, Stephan
AU  - Kramm, Christof
AU  - Donson, Andrew M
AU  - Green, Adam L
AU  - Jones, Chris
AU  - Schittenhelm, Jens
AU  - Ebinger, Martin
AU  - Schuhmann, Martin U
AU  - Jones, Barbara C
AU  - van Tilburg, Cornelis M
AU  - Wittmann, Andrea
AU  - Golanov, Andrey
AU  - Ryzhova, Marina
AU  - Ecker, Jonas
AU  - Milde, Till
AU  - Witt, Olaf
AU  - Sahm, Felix
AU  - Reuss, David
AU  - Sumerauer, David
AU  - Zamecnik, Josef
AU  - Korshunov, Andrey
AU  - von Deimling, Andreas
AU  - Pfister, Stefan M
AU  - Jones, David
TI  - Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B.
JO  - Nature Communications
VL  - 12
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - DKFZ-2021-02126
SP  - 5530
PY  - 2021
N1  - #EA:B360#LA:B360#
AB  - Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n = 23) and ALL (n = 9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2, uncovering diagnostic markers and potentially actionable targets.
LB  - PUB:(DE-HGF)16
C6  - pmid:34545083
C2  - pmc:PMC8452680
DO  - DOI:10.1038/s41467-021-25708-y
UR  - https://inrepo02.dkfz.de/record/176884
ER  -