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@ARTICLE{Deng:176884,
      author       = {M. Y. Deng$^*$ and D. Sturm$^*$ and E. Pfaff$^*$ and M.
                      Sill$^*$ and D. Stichel$^*$ and G. P. Balasubramanian$^*$
                      and S. Tippelt and C. Kramm and A. M. Donson and A. L. Green
                      and C. Jones and J. Schittenhelm and M. Ebinger and M. U.
                      Schuhmann and B. C. Jones$^*$ and C. M. van Tilburg$^*$ and
                      A. Wittmann$^*$ and A. Golanov and M. Ryzhova and J.
                      Ecker$^*$ and T. Milde$^*$ and O. Witt$^*$ and F. Sahm$^*$
                      and D. Reuss$^*$ and D. Sumerauer and J. Zamecnik and A.
                      Korshunov$^*$ and A. von Deimling$^*$ and S. M. Pfister$^*$
                      and D. Jones$^*$},
      title        = {{R}adiation-induced gliomas represent {H}3-/{IDH}-wild type
                      pediatric gliomas with recurrent {PDGFRA} amplification and
                      loss of {CDKN}2{A}/{B}.},
      journal      = {Nature Communications},
      volume       = {12},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2021-02126},
      pages        = {5530},
      year         = {2021},
      note         = {#EA:B360#LA:B360#},
      abstract     = {Long-term complications such as radiation-induced second
                      malignancies occur in a subset of patients following
                      radiation-therapy, particularly relevant in pediatric
                      patients due to the long follow-up period in case of
                      survival. Radiation-induced gliomas (RIGs) have been
                      reported in patients after treatment with cranial
                      irradiation for various primary malignancies such as acute
                      lymphoblastic leukemia (ALL) and medulloblastoma (MB). We
                      perform comprehensive (epi-) genetic and expression
                      profiling of RIGs arising after cranial irradiation for MB
                      (n = 23) and ALL (n = 9). Our study reveals a unifying
                      molecular signature for the majority of RIGs, with recurrent
                      PDGFRA amplification and loss of CDKN2A/B and an absence of
                      somatic hotspot mutations in genes encoding histone 3
                      variants or IDH1/2, uncovering diagnostic markers and
                      potentially actionable targets.},
      cin          = {B360 / B062 / HD01 / B300 / B310},
      ddc          = {500},
      cid          = {I:(DE-He78)B360-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)B300-20160331 /
                      I:(DE-He78)B310-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34545083},
      pmc          = {pmc:PMC8452680},
      doi          = {10.1038/s41467-021-25708-y},
      url          = {https://inrepo02.dkfz.de/record/176884},
}