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| Home > Publications database > Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B. > print |
| Home > Publications database > Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B. > print |
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| 024 | 7 | _ | |a 10.1038/s41467-021-25708-y |2 doi |
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| 100 | 1 | _ | |a Deng, Maximilian Yuanzhe |0 P:(DE-He78)ce7d0cd1f5edc5c0e08c39b3fdd7b410 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B. |
| 260 | _ | _ | |a [London] |c 2021 |b Nature Publishing Group UK |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n = 23) and ALL (n = 9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2, uncovering diagnostic markers and potentially actionable targets. |
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| 700 | 1 | _ | |a Kramm, Christof |b 7 |
| 700 | 1 | _ | |a Donson, Andrew M |b 8 |
| 700 | 1 | _ | |a Green, Adam L |0 0000-0002-4469-2358 |b 9 |
| 700 | 1 | _ | |a Jones, Chris |b 10 |
| 700 | 1 | _ | |a Schittenhelm, Jens |0 0000-0002-9168-6209 |b 11 |
| 700 | 1 | _ | |a Ebinger, Martin |0 0000-0002-4229-8058 |b 12 |
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| 700 | 1 | _ | |a Jones, David |0 P:(DE-He78)551bb92841f634070997aa168d818492 |b 29 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1038/s41467-021-25708-y |g Vol. 12, no. 1, p. 5530 |0 PERI:(DE-600)2553671-0 |n 1 |p 5530 |t Nature Communications |v 12 |y 2021 |x 2041-1723 |
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