%0 Journal Article
%A Ruhm, Loreen
%A Avdievich, Nikolai
%A Ziegs, Theresia
%A Nagel, Armin M
%A De Feyter, Henk M
%A de Graaf, Robin A
%A Henning, Anke
%T Deuterium Metabolic Imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution.
%J NeuroImage
%V 244
%@ 1053-8119
%C Orlando, Fla.
%I Academic Press
%M DKFZ-2021-02241
%P 118639
%D 2021
%Z 2021 Dec 1;244:118639
%X To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects.The study was performed with a double-tuned coil with 10 TxRx channels for 1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min.The metabolism of [6,6'-2H2]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain.X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.
%K 9.4 Tesla (Other)
%K DMI (Other)
%K TCA cycle (Other)
%K deuterium (Other)
%K human brain (Other)
%K oral glucose administration (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34637905
%R 10.1016/j.neuroimage.2021.118639
%U https://inrepo02.dkfz.de/record/177011