Journal Article

DKFZ-2021-02241

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Deuterium Metabolic Imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution.

Ruhm, L. ; Avdievich, N. ; Ziegs, T. ; Nagel, A. M.DKFZ* ; De Feyter, H. M. ; de Graaf, R. A. ; Henning, A.

2021
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.neuroimage.2021.118639

Abstract: To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects.The study was performed with a double-tuned coil with 10 TxRx channels for 1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min.The metabolism of [6,6'-2H2]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain.X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.

Keyword(s): 9.4 Tesla ; DMI ; TCA cycle ; deuterium ; human brain ; oral glucose administration

Note: 2021 Dec 1;244:118639

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Contributing Institute(s):

1. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2021

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