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000177011 1001_ $$aRuhm, Loreen$$b0
000177011 245__ $$aDeuterium Metabolic Imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution.
000177011 260__ $$aOrlando, Fla.$$bAcademic Press$$c2021
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000177011 520__ $$aTo present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects.The study was performed with a double-tuned coil with 10 TxRx channels for 1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min.The metabolism of [6,6'-2H2]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain.X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.
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000177011 650_7 $$2Other$$a9.4 Tesla
000177011 650_7 $$2Other$$aDMI
000177011 650_7 $$2Other$$aTCA cycle
000177011 650_7 $$2Other$$adeuterium
000177011 650_7 $$2Other$$ahuman brain
000177011 650_7 $$2Other$$aoral glucose administration
000177011 7001_ $$aAvdievich, Nikolai$$b1
000177011 7001_ $$aZiegs, Theresia$$b2
000177011 7001_ $$0P:(DE-He78)054fd7a5195b75b11fbdc5c360276011$$aNagel, Armin M$$b3$$udkfz
000177011 7001_ $$aDe Feyter, Henk M$$b4
000177011 7001_ $$ade Graaf, Robin A$$b5
000177011 7001_ $$aHenning, Anke$$b6
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