TY  - JOUR
AU  - Ruhm, Loreen
AU  - Avdievich, Nikolai
AU  - Ziegs, Theresia
AU  - Nagel, Armin M
AU  - De Feyter, Henk M
AU  - de Graaf, Robin A
AU  - Henning, Anke
TI  - Deuterium Metabolic Imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution.
JO  - NeuroImage
VL  - 244
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - DKFZ-2021-02241
SP  - 118639
PY  - 2021
N1  - 2021 Dec 1;244:118639
AB  - To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects.The study was performed with a double-tuned coil with 10 TxRx channels for 1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min.The metabolism of [6,6'-2H2]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain.X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.
KW  - 9.4 Tesla (Other)
KW  - DMI (Other)
KW  - TCA cycle (Other)
KW  - deuterium (Other)
KW  - human brain (Other)
KW  - oral glucose administration (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34637905
DO  - DOI:10.1016/j.neuroimage.2021.118639
UR  - https://inrepo02.dkfz.de/record/177011
ER  -