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@ARTICLE{Ruhm:177011,
      author       = {L. Ruhm and N. Avdievich and T. Ziegs and A. M. Nagel$^*$
                      and H. M. De Feyter and R. A. de Graaf and A. Henning},
      title        = {{D}euterium {M}etabolic {I}maging in the human brain at 9.4
                      {T}esla with high spatial and temporal resolution.},
      journal      = {NeuroImage},
      volume       = {244},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DKFZ-2021-02241},
      pages        = {118639},
      year         = {2021},
      note         = {2021 Dec 1;244:118639},
      abstract     = {To present first highly spatially resolved deuterium
                      metabolic imaging (DMI) measurements of the human brain
                      acquired with a dedicated coil design and a fast chemical
                      shift imaging (CSI) sequence at an ultrahigh field strength
                      of B0 = 9.4 T. 2H metabolic measurements with a temporal
                      resolution of 10 min enabled the investigation of the
                      glucose metabolism in healthy human subjects.The study was
                      performed with a double-tuned coil with 10 TxRx channels for
                      1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI
                      sequence with a nominal spatial resolution of 2.97 ml and a
                      temporal resolution of 10 min.The metabolism of
                      [6,6'-2H2]-labeled glucose due to the TCA cycle could be
                      made visible in high resolution metabolite images of
                      deuterated water, glucose and Glx over the entire human
                      brain.X-nuclei MRSI as DMI can highly benefit from ultrahigh
                      field strength enabling higher temporal and spatial
                      resolutions.},
      keywords     = {9.4 Tesla (Other) / DMI (Other) / TCA cycle (Other) /
                      deuterium (Other) / human brain (Other) / oral glucose
                      administration (Other)},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34637905},
      doi          = {10.1016/j.neuroimage.2021.118639},
      url          = {https://inrepo02.dkfz.de/record/177011},
}