TY  - JOUR
AU  - Gambichler, Thilo
AU  - Boms, Stefanie
AU  - Susok, Laura
AU  - Dickel, Heinrich
AU  - Finis, Cansu
AU  - Abu Rached, Nessr
AU  - Barras, Milan
AU  - Stücker, Markus
AU  - Kasakovski, Dimitri
TI  - Cutaneous findings following COVID-19 vaccination: Review of world literature and own experience.
JO  - Journal of the European Academy of Dermatology and Venereology
VL  - 36
IS  - 2
SN  - 0926-9959
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DKFZ-2021-02290
SP  - 172-180
PY  - 2022
N1  - 2022 Feb;36(2):172-180
AB  - There is growing evidence that not only the novel coronavirus disease (COVID-19) but also the COVID-19 vaccines can cause a variety of skin reactions. In this review article, we provide a brief overview on cutaneous findings that have been observed since the emerging mass COVID-19 vaccination campaigns all over the world. Unspecific injection site reactions very early occurring after the vaccination are most frequent. Type I hypersensitivity reactions (e.g., urticaria, angioedema, anaphylaxis) likely due to allergy to ingredients may rarely occur but can be severe. Type IV hypersensitivity reactions may be observed, including delayed large local skin lesions ('COVID arm'), inflammatory reactions in dermal filler or previous radiation sites or even old BCG scars, and more commonly moribilliform and erythema multiforme-like rashes. Autoimmune-mediated skin findings after COVID-19 vaccination include leukocytoclastic vasculitis, lupus erythematosus, and immune thrombocytopenia. Functional angiopathies (chilblain-like lesions, erythromelalgia) may also be observed. Pityriasis rosea-like rashes and reactivation of herpes zoster have also been reported after COVID-19 vaccination. In conclusion, there are numerous cutaneous reaction patterns that may occur following COVID-19 vaccination, whereby many of these skin findings are of immunological/autoimmunological nature. Importantly, molecular mimicry exists between SARS-CoV-2 (e.g., the spike-protein sequences used to design the vaccines) and human components and may thus explain some COVID-19 pathologies as well adverse skin reactions to COVID-19 vaccinations.
KW  - COVID-19 (Other)
KW  - SARS-CoV-2 (Other)
KW  - adverse events (Other)
KW  - coronavirus (Other)
KW  - cutaneous reactions (Other)
KW  - molecular mimicry (Other)
KW  - side-effects (Other)
KW  - skin (Other)
KW  - vaccination (Other)
KW  - vaccine (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34661927
DO  - DOI:10.1111/jdv.17744
UR  - https://inrepo02.dkfz.de/record/177084
ER  -