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000177324 1001_ $$0P:(DE-He78)a9114d386dffd6b8746b19b19beed7d2$$aBlobner, Jens$$b0$$eFirst author$$udkfz
000177324 245__ $$aComparative evaluation of T-cell receptors in experimental glioma-draining lymph nodes.
000177324 260__ $$aOxford$$bOxford University Press$$c2021
000177324 264_1 $$2Crossref$$3online$$bOxford University Press (OUP)$$c2021-09-28
000177324 264_1 $$2Crossref$$3print$$bOxford University Press (OUP)$$c2021-01-01
000177324 264_1 $$2Crossref$$3print$$bOxford University Press (OUP)$$c2021-01-01
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000177324 520__ $$aGlioblastomas, the most common primary malignant brain tumors, are considered immunologically cold malignancies due to growth in an immune sanctuary site. While peptide vaccines have shown to generate intra-tumoral antigen-specific T cells, the identification of these tumor-specific T cells is challenging and requires detailed analyses of tumor tissue. Several studies have shown that CNS antigens may be transported via lymphatic drainage to cervical lymph nodes, where antigen-specific T-cell responses can be generated. Therefore, we investigated whether glioma-draining lymph nodes (TDLN) may constitute a reservoir of tumor-reactive T cells.We addressed our hypothesis by flow cytometric analyses of chicken ovalbumin (OVA)-specific CD8+ T cells as well as T-cell receptor beta (TCRβ) next-generation-sequencing (TCRβ-NGS) of T cells from tumor tissue, TDLN, spleen, and inguinal lymph nodes harvested from experimental mouse GL261 glioma models.Longitudinal dextramer-based assessment of specific CD8+ T cells from TDLN did not show tumor model antigen reactivity. Unbiased immunogenomic analysis revealed a low overlap of TCRβ sequences from glioma-infiltrating CD8+ T cells between mice. Enrichment scores, calculated by the ratio of productive frequencies of the different TCRβ-CDR3 amino-acid (aa) rearrangements of CD8+ T cells derived from tumor, TDLN, inguinal lymph nodes, and spleen demonstrated a higher proportion of tumor-associated TCR in the spleen compared to TDLN.In experimental glioblastoma, our data did not provide evidence that glioma-draining cervical lymph nodes are a robust reservoir for spontaneous glioma-specific T cells highlighting the requirement for detailed analyses of glioma-infiltrating T cells for the discovery of tumor-specific TCR.
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000177324 542__ $$2Crossref$$i2021-09-28$$uhttps://creativecommons.org/licenses/by-nc/4.0/
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000177324 650_7 $$2Other$$aTCR discovery
000177324 650_7 $$2Other$$aglioblastoma
000177324 650_7 $$2Other$$aglioma draining lymph nodes
000177324 7001_ $$0P:(DE-He78)bed62b0b74cf1048663fbefeb4b5d7bc$$aKilian, Michael$$b1$$udkfz
000177324 7001_ $$0P:(DE-He78)c78afd4e9332b1120bda149010bb3633$$aTan, Chin Leng$$b2$$udkfz
000177324 7001_ $$0P:(DE-HGF)0$$aAslan, Katrin$$b3
000177324 7001_ $$0P:(DE-He78)ca9f3aa4fcee93af10f7e792516e7193$$aSanghvi, Khwab$$b4$$udkfz
000177324 7001_ $$0P:(DE-He78)b6273c0ba3ae37a4d3d1c6b084797f2e$$aMeyer, Jochen$$b5$$udkfz
000177324 7001_ $$aFischer, Manuel$$b6
000177324 7001_ $$0P:(DE-He78)106aed16a97ff393cca5528582f8c655$$aJähne, Kristine$$b7$$udkfz
000177324 7001_ $$0P:(DE-He78)5ba5b48bd126214d9cb66291fa4ae303$$aBreckwoldt, Michael O$$b8$$udkfz
000177324 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b9$$udkfz
000177324 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b10$$udkfz
000177324 7001_ $$aBendszus, Martin$$b11
000177324 7001_ $$0P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aWick, Wolfgang$$b12$$udkfz
000177324 7001_ $$0P:(DE-He78)5ef8651b0f857b9c640aa5b1498c43b5$$aPlatten, Michael$$b13$$udkfz
000177324 7001_ $$0P:(DE-He78)9b97ca569bcb00dfda69382bc7261700$$aGreen, Edward$$b14$$udkfz
000177324 7001_ $$0P:(DE-He78)e579130c57e8c686ed1c2dedfa595985$$aBunse, Lukas$$b15$$eLast author$$udkfz
000177324 77318 $$2Crossref$$3journal-article$$a10.1093/noajnl/vdab147$$bOxford University Press (OUP)$$d2021-01-01$$n1$$tNeuro-Oncology Advances$$v3$$x2632-2498$$y2021
000177324 773__ $$0PERI:(DE-600)3009682-0$$a10.1093/noajnl/vdab147$$gVol. 3, no. 1, p. vdab147$$n1$$pvdab147$$tNeuro-oncology advances$$v3$$x2632-2498$$y2021
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000177324 999C5 $$1Stupp$$2Crossref$$9-- missing cx lookup --$$a10.1056/NEJMoa043330$$p987 -$$tN Engl J Med.$$v352$$y2005
000177324 999C5 $$1Medawar$$2Crossref$$oMedawar 1948$$y1948
000177324 999C5 $$1Carson$$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1600-065X.2006.00441.x$$p48 -$$tImmunol Rev.$$v213$$y2006
000177324 999C5 $$1Louveau$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41593-018-0227-9$$p1380 -$$tNat Neurosci.$$v21$$y2018
000177324 999C5 $$1Hsu$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41467-018-08163-0$$p229 -$$tNat Commun.$$v10$$y2019
000177324 999C5 $$1Louveau$$2Crossref$$9-- missing cx lookup --$$a10.1038/nature14432$$p337 -$$tNature.$$v523$$y2015
000177324 999C5 $$1Li$$2Crossref$$9-- missing cx lookup --$$a10.1038/ng.3581$$p725 -$$tNat Genet.$$v48$$y2016
000177324 999C5 $$1Thorsson$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.immuni.2018.03.023$$p812 -$$tImmunity.$$v48$$y2018
000177324 999C5 $$1Jack$$2Crossref$$oJack 2015$$y2015
000177324 999C5 $$1Wilson$$2Crossref$$9-- missing cx lookup --$$a10.1172/JCI41911$$p1368 -$$tJ Clin Invest.$$v120$$y2010
000177324 999C5 $$1Platten$$2Crossref$$9-- missing cx lookup --$$a10.1007/s11910-014-0440-1$$p440 -$$tCurr Neurol Neurosci Rep.$$v14$$y2014
000177324 999C5 $$1Johanns$$2Crossref$$9-- missing cx lookup --$$a10.1158/2159-8290.CD-16-0575$$p1230 -$$tCancer Discov.$$v6$$y2016
000177324 999C5 $$1Bouffet$$2Crossref$$9-- missing cx lookup --$$a10.1200/JCO.2016.66.6552$$p2206 -$$tJ Clin Oncol.$$v34$$y2016
000177324 999C5 $$1Platten$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41586-021-03363-z$$p463 -$$tNature.$$v592$$y2021
000177324 999C5 $$1Schumacher$$2Crossref$$9-- missing cx lookup --$$a10.4161/2162402X.2014.974392$$pe974392 -$$tOncoimmunology.$$v3$$y2014
000177324 999C5 $$1Ochs$$2Crossref$$9-- missing cx lookup --$$a10.1080/2162402X.2017.1328340$$pe1328340 -$$tOncoimmunology.$$v6$$y2017
000177324 999C5 $$1Schumacher$$2Crossref$$9-- missing cx lookup --$$a10.1038/nature13387$$p324 -$$tNature.$$v512$$y2014
000177324 999C5 $$1Hilf$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41586-018-0810-y$$p240 -$$tNature.$$v565$$y2019
000177324 999C5 $$1Breckwoldt$$2Crossref$$9-- missing cx lookup --$$a10.7554/eLife.11712$$pe11712 -$$tElife.$$v5$$y2016
000177324 999C5 $$1Keil$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jneuroim.2016.05.014$$p117 -$$tJ Neuroimmunol.$$v297$$y2016
000177324 999C5 $$1Carlson$$2Crossref$$9-- missing cx lookup --$$a10.1038/ncomms3680$$p2680 -$$tNat Commun.$$v4$$y2013
000177324 999C5 $$1Bagaev$$2Crossref$$9-- missing cx lookup --$$a10.1186/s12864-016-2799-7$$p453 -$$tBMC Genomics.$$v17$$y2016
000177324 999C5 $$1Sidhom$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41467-021-21879-w$$p1605 -$$tNat Commun$$v2021
000177324 999C5 $$1Poschke$$2Crossref$$9-- missing cx lookup --$$a10.1080/2162402X.2016.1240859$$pe1240859 -$$tOncoimmunology.$$v5$$y2016
000177324 999C5 $$1Munson$$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1606994113$$p8272 -$$tProc Natl Acad Sci U S A.$$v113$$y2016
000177324 999C5 $$1Massa$$2Crossref$$9-- missing cx lookup --$$a10.18632/oncotarget.15064$$p21212 -$$tOncotarget.$$v8$$y2017
000177324 999C5 $$1Aspelund$$2Crossref$$9-- missing cx lookup --$$a10.1084/jem.20142290$$p991 -$$tJ Exp Med.$$v212$$y2015
000177324 999C5 $$1Louveau$$2Crossref$$9-- missing cx lookup --$$a10.1172/JCI90603$$p3210 -$$tJ Clin Invest.$$v127$$y2017
000177324 999C5 $$1Kaminski$$2Crossref$$9-- missing cx lookup --$$a10.1189/jlb.0511241$$p31 -$$tJ Leukoc Biol.$$v92$$y2012
000177324 999C5 $$1Aslan$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41467-020-14642-0$$p931 -$$tNat Commun.$$v11$$y2020
000177324 999C5 $$1Reardon$$2Crossref$$9-- missing cx lookup --$$a10.1158/2326-6066.CIR-15-0151$$p124 -$$tCancer Immunol Res.$$v4$$y2016
000177324 999C5 $$2Crossref$$o
000177324 999C5 $$1Hu$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41591-020-01206-4$$p515–525 -$$tNat Med.$$v27$$y2021
000177324 999C5 $$1Kida$$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1365-2990.1993.tb00476.x$$p480 -$$tNeuropathol Appl Neurobiol.$$v19$$y1993
000177324 999C5 $$1Cserr$$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1750-3639.1992.tb00703.x$$p269 -$$tBrain Pathol.$$v2$$y1992
000177324 999C5 $$1Mitchell$$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1600-065X.2008.00603.x$$p70 -$$tImmunol Rev.$$v222$$y2008
000177324 999C5 $$1Munn$$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1600-065X.2006.00444.x$$p146 -$$tImmunol Rev.$$v213$$y2006
000177324 999C5 $$1Munn$$2Crossref$$9-- missing cx lookup --$$a10.1172/JCI21583$$p280 -$$tJ Clin Invest.$$v114$$y2004
000177324 999C5 $$1Sharma$$2Crossref$$9-- missing cx lookup --$$a10.1172/JCI31911$$p2570 -$$tJ Clin Invest.$$v117$$y2007
000177324 999C5 $$1Kim$$2Crossref$$9-- missing cx lookup --$$a10.1158/0008-5472.CAN-05-4128$$p5527 -$$tCancer Res.$$v66$$y2006
000177324 999C5 $$1Mempel$$2Crossref$$9-- missing cx lookup --$$a10.1038/nature02238$$p154 -$$tNature.$$v427$$y2004
000177324 999C5 $$1Alitalo$$2Crossref$$9-- missing cx lookup --$$a10.1038/nm.2545$$p1371 -$$tNat Med.$$v17$$y2011
000177324 999C5 $$1Kerjaschki$$2Crossref$$9-- missing cx lookup --$$a10.1172/JCI74854$$p874 -$$tJ Clin Invest.$$v124$$y2014
000177324 999C5 $$1Sweet$$2Crossref$$9-- missing cx lookup --$$a10.1172/JCI79386$$p2995 -$$tJ Clin Invest.$$v125$$y2015
000177324 999C5 $$1Raper$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tins.2016.07.001$$p581 -$$tTrends Neurosci.$$v39$$y2016
000177324 999C5 $$1Simoni$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41586-018-0130-2$$p575 -$$tNature.$$v557$$y2018
000177324 999C5 $$1Simon$$2Crossref$$9-- missing cx lookup --$$a10.1080/2162402X.2017.1364828$$pe1364828 -$$tOncoimmunology.$$v7$$y2017
000177324 999C5 $$1Gros$$2Crossref$$9-- missing cx lookup --$$a10.1172/JCI73639$$p2246 -$$tJ Clin Invest.$$v124$$y2014
000177324 999C5 $$1Yossef$$2Crossref$$9-- missing cx lookup --$$a10.1172/jci.insight.122467$$pe122467 -$$tJCI Insight$$v3$$y2018
000177324 999C5 $$1Riaz$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2017.09.028$$p934 -$$tCell.$$v171$$y2017