000177446 001__ 177446
000177446 005__ 20240229133740.0
000177446 037__ $$aDKFZ-2021-02538
000177446 1001_ $$0P:(DE-He78)02e29e2d540ff21d777f3a03ec9f5ade$$aJansen, Jeannette$$b0$$udkfz
000177446 1112_ $$aPTCOG 59$$cTaipei$$d2021-06-04 - 2021-06-07$$wTaiwan
000177446 245__ $$aImplementation of an online oxygen meter for studying oxygen removal during FLASH irradiation
000177446 260__ $$c2021
000177446 3367_ $$033$$2EndNote$$aConference Paper
000177446 3367_ $$2DataCite$$aOther
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000177446 3367_ $$0PUB:(DE-HGF)6$$2PUB:(DE-HGF)$$aConference Presentation$$bconf$$mconf$$s1637151810_23141$$xInvited
000177446 520__ $$aAlternatively to the commonly used conventional radiotherapies (RT) using X-Rays or protons and heavier ions, the treatment with high dose rates, known as FLASH, is of higher interest since it provides a tumor control probability in the range of conventional radiotherapy and a highly improved sparing of the healthy tissue[1]. This phenomenon is not fully understood yet but one common explanation is the oxygen depletion theory due to which tissue enters a hypoxic state and becomes radioresistant. The presented study aims to characterize this effect by measuring the dependence of oxygen solubilized in water from irradiation with different dose rates and different radiation types. Hereby, the initial amount of oxygen in water is set to a physiological range of 0.5-5%. During radiation, the amount of oxygen is measured using an optical sensor in predefined water phantoms of 500µl – 60 ml volumes. The dependence of oxygen is measured as a function of the irradiated volume, the initial concentration of oxygen, the dose rate, the total dose and the particle type. First experiments with an irradiated phantom coupled to an unirradiated part serving as oxygen supply have shown that the percentage of depleted oxygen is independent on the dose rate but the total irradiation time (see Fig 1) and total dose (see Tab 1) needed to reach a saturation point is highly dependend on the dose rate.
000177446 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000177446 7001_ $$0P:(DE-He78)483e25de20b0e09c44b46bdbdd7036c2$$aKnoll, Jan$$b1$$udkfz
000177446 7001_ $$0P:(DE-He78)d06e5bb2d0828caa2be79a51825e84e1$$aPagliari, Francesca$$b2$$udkfz
000177446 7001_ $$0P:(DE-He78)102624aca75cfe987c05343d5fdcf2fe$$aSeco, Joao$$b3$$eCorresponding author$$udkfz
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000177446 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)02e29e2d540ff21d777f3a03ec9f5ade$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000177446 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)483e25de20b0e09c44b46bdbdd7036c2$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000177446 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d06e5bb2d0828caa2be79a51825e84e1$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000177446 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)102624aca75cfe987c05343d5fdcf2fe$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
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000177446 9141_ $$y2021
000177446 9201_ $$0I:(DE-He78)E041-20160331$$kE041$$lE041 Medizinische Physik in der Radioonkologie$$x0
000177446 980__ $$aconf
000177446 980__ $$aVDB
000177446 980__ $$aI:(DE-He78)E041-20160331
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