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| Home > Publications database > Implementation of an online oxygen meter for studying oxygen removal during FLASH irradiation |
| Conference Presentation (Invited) | DKFZ-2021-02538 |
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2021
Abstract: Alternatively to the commonly used conventional radiotherapies (RT) using X-Rays or protons and heavier ions, the treatment with high dose rates, known as FLASH, is of higher interest since it provides a tumor control probability in the range of conventional radiotherapy and a highly improved sparing of the healthy tissue[1]. This phenomenon is not fully understood yet but one common explanation is the oxygen depletion theory due to which tissue enters a hypoxic state and becomes radioresistant. The presented study aims to characterize this effect by measuring the dependence of oxygen solubilized in water from irradiation with different dose rates and different radiation types. Hereby, the initial amount of oxygen in water is set to a physiological range of 0.5-5%. During radiation, the amount of oxygen is measured using an optical sensor in predefined water phantoms of 500µl – 60 ml volumes. The dependence of oxygen is measured as a function of the irradiated volume, the initial concentration of oxygen, the dose rate, the total dose and the particle type. First experiments with an irradiated phantom coupled to an unirradiated part serving as oxygen supply have shown that the percentage of depleted oxygen is independent on the dose rate but the total irradiation time (see Fig 1) and total dose (see Tab 1) needed to reach a saturation point is highly dependend on the dose rate.
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