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@INPROCEEDINGS{Jansen:177446,
      author       = {J. Jansen$^*$ and J. Knoll$^*$ and F. Pagliari$^*$ and J.
                      Seco$^*$},
      title        = {{I}mplementation of an online oxygen meter for studying
                      oxygen removal during {FLASH} irradiation},
      reportid     = {DKFZ-2021-02538},
      year         = {2021},
      abstract     = {Alternatively to the commonly used conventional
                      radiotherapies (RT) using X-Rays or protons and heavier
                      ions, the treatment with high dose rates, known as FLASH, is
                      of higher interest since it provides a tumor control
                      probability in the range of conventional radiotherapy and a
                      highly improved sparing of the healthy tissue[1]. This
                      phenomenon is not fully understood yet but one common
                      explanation is the oxygen depletion theory due to which
                      tissue enters a hypoxic state and becomes radioresistant.
                      The presented study aims to characterize this effect by
                      measuring the dependence of oxygen solubilized in water from
                      irradiation with different dose rates and different
                      radiation types. Hereby, the initial amount of oxygen in
                      water is set to a physiological range of $0.5-5\%.$ During
                      radiation, the amount of oxygen is measured using an optical
                      sensor in predefined water phantoms of 500µl – 60 ml
                      volumes. The dependence of oxygen is measured as a function
                      of the irradiated volume, the initial concentration of
                      oxygen, the dose rate, the total dose and the particle type.
                      First experiments with an irradiated phantom coupled to an
                      unirradiated part serving as oxygen supply have shown that
                      the percentage of depleted oxygen is independent on the dose
                      rate but the total irradiation time (see Fig 1) and total
                      dose (see Tab 1) needed to reach a saturation point is
                      highly dependend on the dose rate.},
      month         = {Jun},
      date          = {2021-06-04},
      organization  = {PTCOG 59, Taipei (Taiwan), 4 Jun 2021
                       - 7 Jun 2021},
      subtyp        = {Invited},
      cin          = {E041},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://inrepo02.dkfz.de/record/177446},
}