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@MASTERSTHESIS{Milewski:177452,
      author       = {K. Milewski$^*$},
      title        = {{T}he damage response of human cancercells to irradiation
                      under the variation ofthe dose rate and oxygen level},
      school       = {Universität Heidelberg},
      type         = {Bachelorarbeit},
      reportid     = {DKFZ-2021-02544},
      year         = {2021},
      note         = {Corresponding author J. Seco; Bachelorarbeit, Universität
                      Heidelberg, 2021},
      abstract     = {In radiotherapy, it has always been the main objective to
                      effectively treat tumours, while damaginghealthy tissue as
                      little as possible. It has been found in several in vivo
                      studies that irradiation athigh dose rates spares healthy
                      tissue, while remaining the same tumour control as with
                      conventional dose rates, allowing for healthy and cancerous
                      tissue to self-delimit when irradiated withhigh dose rates.
                      In vitro, a sparing effect after irradiation with high dose
                      rates in comparison toconventional dose rates was observed
                      even for cells of the same cell line. This sparing effect
                      iscalled FLASH effect and has been found to be closely
                      related to the oxygen concentration in thecells during the
                      irradiation, but the underlying mechanism is still
                      unclear.Hence this Bachelor’s thesis investigated the
                      damage response of cells of the human pancreaticcancer cell
                      line Panc-1 to the irradiation with X-rays at different dose
                      rates under the influence ofdifferent oxygen concentrations
                      in the cellular environment. Clonogenic cell survival assays
                      havebeen carried out at four different oxygen levels up to 2
                      $\%$ in order to narrow down the oxygenconcentration window,
                      in which the enhancement of radioresistance through high
                      dose rates ispresent.The present experiments have, first of
                      all, confirmed that less oxygenated cells are less
                      radiosensitive. Furthermore, it has been found that the
                      enhancement of the radioresistance of cells throughhigh dose
                      rates diminishes with decreasing oxygen levels and, against
                      all expectations, is strongestunder normoxic conditions.
                      This observation has already been made by an other research
                      group[2] and opens up many new question for further
                      research.},
      cin          = {E041},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)2},
      url          = {https://inrepo02.dkfz.de/record/177452},
}