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@MASTERSTHESIS{Wllner:177454,
      author       = {A. Wüllner$^*$},
      title        = {{T}oxicity studies on lung and pancreatic cancer celllines:
                      {A}n approach towards {FLASH} mechanisms},
      school       = {Universität Heidelberg},
      type         = {Bachelorarbeit},
      reportid     = {DKFZ-2021-02546},
      year         = {2021},
      note         = {Corresponding author J. Seco; Bachelorarbeit, Universität
                      Heidelberg, 2021},
      abstract     = {Several studies have hinted towards involvement of radical
                      scavengers in the sparingof healthy tissue in radiotherapy
                      (RT) for ultra-high dose rates (FLASH effect). Thesaturation
                      of the intracellular enzyme Superoxide Dismutase (SOD) is
                      proposed to playa key role in the FLASH effect. The aim of
                      the current study was to establish treatmentprotocols to
                      achieve $80\%$ cell viability of two cancer cell lines for
                      four compounds thataffect the enzyme and its substrate
                      Superoxide. Cytotoxicity assays were done on theH460 lung
                      cancer cell line and the Panc-1 pancreatic cancer cell line
                      with the compoundsH2O2, MSB, NaCN and KCN. The effect of
                      Catalase on cell viability was tested and theeffect of NaCN
                      treatment in combination with conventional RT and FLASH RT
                      wastested using clonogenic assays on the H460 cell line.
                      Treatment protocols to $achieve80\%$ cell viability were
                      found for all four compounds and cell lines. For almost all
                      celllines a treatment protocol to achieve $50\%$ viability
                      was found. A significant increase ofviability of about
                      $50\%$ was detected for combining NaCN treatment with FLASH
                      RT.Further studies on the effects of the compounds in
                      combination with RT have to be doneas well as on their
                      effect on the SOD levels.},
      cin          = {E041},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)2},
      url          = {https://inrepo02.dkfz.de/record/177454},
}