000177456 001__ 177456
000177456 005__ 20240229133741.0
000177456 037__ $$aDKFZ-2021-02548
000177456 1001_ $$0P:(DE-HGF)0$$aEspinha, Claudia$$b0
000177456 245__ $$aA Computational Model for Radiotherapy Studieswith Proton and Carbon ion Mini-Beams
000177456 260__ $$c2021
000177456 3367_ $$2DataCite$$aOutput Types/Supervised Student Publication
000177456 3367_ $$02$$2EndNote$$aThesis
000177456 3367_ $$2BibTeX$$aMASTERSTHESIS
000177456 3367_ $$2DRIVER$$amasterThesis
000177456 3367_ $$0PUB:(DE-HGF)19$$2PUB:(DE-HGF)$$aMaster Thesis$$bmaster$$mmaster$$s1637151317_19386
000177456 3367_ $$2ORCID$$aSUPERVISED_STUDENT_PUBLICATION
000177456 500__ $$aCorresponding author: J. Seco
000177456 502__ $$aMasterarbeit, IST, University of Lisbon, 2021$$bMasterarbeit$$cIST, University of Lisbon$$gFaculty of Biomedical Engineering
000177456 520__ $$aThe technological developments play an important role in the improvement of cancer therapy.Radiation-therapy is rapidly evolving field, used as a form of treatment for as many as half the cancerpatients [1].Mini-Beam radiotherapy (MBRT) is a developing new technique that has been investigated withboth x-rays and proton beams and has shown good results in reducing the side effects in the tissuessurrounding the carcinogenic cells. MBRT has been investigated at two different spatial scales, bothmini and micro scale. In this thesis, we will only focus on mini-beam radiotherapy.MBRT uses a spatial pattern of high-dose beamlets alternating with low-dose valleys. The setuputilizes arrays of parallel thin radiation planes separated by short distances. This way, the reductionof the side effects in the organs at risk is not achieved by reducing their integral dose, but due toa differential response of normal and tumor tissues to the radiation delivered with a well definedspatial fractionation [2].The beam setup of MBRT allows the physical dose delivered in the valleys to be small comparedto the average dose delivered in the tumor which leads to a significant part of the tumor volume to beunder-dosed. Some studies proposed that the tumor control is a consequence of the level of reactiveoxygen species in the cells, more precisely from some of the products of water radiolysis.In this work the behaviour of the products of radiolysis using TOPAs-nBio is studied to evaluatethe effects in the micro scale. This study consists in two phases: first the analysis of the G-valueevolution with time and then the analysis of the diffusion of some water radiolysis products.Furthermore, a TOPAS calibration was performed both for protons and carbon ions to understandthe precision of the TOPAS results and also to prepare a base for future comparisons with clinicalresults
000177456 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000177456 909CO $$ooai:inrepo02.dkfz.de:177456$$pVDB
000177456 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000177456 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000177456 9141_ $$y2021
000177456 9201_ $$0I:(DE-He78)E041-20160331$$kE041$$lE041 Medizinische Physik in der Radioonkologie$$x0
000177456 980__ $$amaster
000177456 980__ $$aVDB
000177456 980__ $$aI:(DE-He78)E041-20160331
000177456 980__ $$aUNRESTRICTED