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| Home > Publications database > A Computational Model for Radiotherapy Studieswith Proton and Carbon ion Mini-Beams |
| Master Thesis | DKFZ-2021-02548 |
2021
Abstract: The technological developments play an important role in the improvement of cancer therapy.Radiation-therapy is rapidly evolving field, used as a form of treatment for as many as half the cancerpatients [1].Mini-Beam radiotherapy (MBRT) is a developing new technique that has been investigated withboth x-rays and proton beams and has shown good results in reducing the side effects in the tissuessurrounding the carcinogenic cells. MBRT has been investigated at two different spatial scales, bothmini and micro scale. In this thesis, we will only focus on mini-beam radiotherapy.MBRT uses a spatial pattern of high-dose beamlets alternating with low-dose valleys. The setuputilizes arrays of parallel thin radiation planes separated by short distances. This way, the reductionof the side effects in the organs at risk is not achieved by reducing their integral dose, but due toa differential response of normal and tumor tissues to the radiation delivered with a well definedspatial fractionation [2].The beam setup of MBRT allows the physical dose delivered in the valleys to be small comparedto the average dose delivered in the tumor which leads to a significant part of the tumor volume to beunder-dosed. Some studies proposed that the tumor control is a consequence of the level of reactiveoxygen species in the cells, more precisely from some of the products of water radiolysis.In this work the behaviour of the products of radiolysis using TOPAs-nBio is studied to evaluatethe effects in the micro scale. This study consists in two phases: first the analysis of the G-valueevolution with time and then the analysis of the diffusion of some water radiolysis products.Furthermore, a TOPAS calibration was performed both for protons and carbon ions to understandthe precision of the TOPAS results and also to prepare a base for future comparisons with clinicalresults
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