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000178167 0247_ $$2doi$$a10.1053/j.gastro.2021.12.239
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000178167 041__ $$aEnglish
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000178167 1001_ $$0P:(DE-He78)40c45b31a82f8311dd3a7363bd758720$$aLi, Hengjing$$b0$$eFirst author$$udkfz
000178167 245__ $$aAssociations of body mass index at different ages with early-onset colorectal cancer.
000178167 260__ $$aPhiladelphia, Pa. [u.a.]$$bSaunders$$c2022
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000178167 500__ $$a#EA:C070#LA:C070#LA:C120# / Volume 162, Issue 4, April 2022, Pages 1088-1097.e3
000178167 520__ $$aIncidence of colorectal cancer (CRC) in younger adults is increasing in many countries. Given the established association of body mass index (BMI) with CRC risk and the increasing obesity prevalence among younger generations, we aimed to evaluate the association of BMI at different ages during early adulthood with early-onset CRC.Among 6602 CRC patients and 7950 matched controls who were recruited in 2003-2020 in the DACHS study, a population-based case-control study from Germany, 747 patients and 621 controls were below age 55 and included in this analysis. Self-reported height and weight at ages 20 and 30 years, and at approximately 10 years before diagnosis or interview were recorded in personal interviews. Associations of BMI with early-onset CRC were estimated using multiple logistic regression.Compared to participants with BMI <25 kg/m2, those with BMI ≥30 kg/m2 (obesity) at age 20 and 30 years and approximately 10 years before diagnosis/interview had 2.56 (95% CI 1.20-5.44), 2.06 (1.25-3.40), and 1.88 (1.30-2.73) fold risk of early-onset CRC. The association of BMI with early-onset CRC risk was particularly pronounced among and essentially restricted to the majority of participants with no previous colonoscopy.Obesity at early adulthood is strongly associated with increased risk of early- onset CRC.
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000178167 650_7 $$2Other$$abody mass index
000178167 650_7 $$2Other$$acolorectal cancer
000178167 650_7 $$2Other$$aearly-onset colorectal cancer
000178167 650_7 $$2Other$$aobesity
000178167 7001_ $$0P:(DE-He78)657300dfd28903ec8149ca9bf5e7968d$$aBoakye, Daniel$$b1
000178167 7001_ $$0P:(DE-He78)c392ec8a090dcfbe801f135a6212caf9$$aChen, Xuechen$$b2$$udkfz
000178167 7001_ $$0P:(DE-He78)bbfe0ebad1e3b608bca2b49d4f86bd09$$aJansen, Lina$$b3$$udkfz
000178167 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b4$$udkfz
000178167 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b5$$udkfz
000178167 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b6$$eLast author$$udkfz
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