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| Home > Publications database > Associations of body mass index at different ages with early-onset colorectal cancer. |
| Journal Article | DKFZ-2021-03172 |
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2022
Saunders
Philadelphia, Pa. [u.a.]
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Please use a persistent id in citations: doi:10.1053/j.gastro.2021.12.239
Abstract: Incidence of colorectal cancer (CRC) in younger adults is increasing in many countries. Given the established association of body mass index (BMI) with CRC risk and the increasing obesity prevalence among younger generations, we aimed to evaluate the association of BMI at different ages during early adulthood with early-onset CRC.Among 6602 CRC patients and 7950 matched controls who were recruited in 2003-2020 in the DACHS study, a population-based case-control study from Germany, 747 patients and 621 controls were below age 55 and included in this analysis. Self-reported height and weight at ages 20 and 30 years, and at approximately 10 years before diagnosis or interview were recorded in personal interviews. Associations of BMI with early-onset CRC were estimated using multiple logistic regression.Compared to participants with BMI <25 kg/m2, those with BMI ≥30 kg/m2 (obesity) at age 20 and 30 years and approximately 10 years before diagnosis/interview had 2.56 (95% CI 1.20-5.44), 2.06 (1.25-3.40), and 1.88 (1.30-2.73) fold risk of early-onset CRC. The association of BMI with early-onset CRC risk was particularly pronounced among and essentially restricted to the majority of participants with no previous colonoscopy.Obesity at early adulthood is strongly associated with increased risk of early- onset CRC.
Keyword(s): body mass index ; colorectal cancer ; early-onset colorectal cancer ; obesity
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