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@ARTICLE{Li:178167,
      author       = {H. Li$^*$ and D. Boakye$^*$ and X. Chen$^*$ and L.
                      Jansen$^*$ and J. Chang-Claude$^*$ and M. Hoffmeister$^*$
                      and H. Brenner$^*$},
      title        = {{A}ssociations of body mass index at different ages with
                      early-onset colorectal cancer.},
      journal      = {Gastroenterology},
      volume       = {162},
      number       = {4},
      issn         = {0016-5085},
      address      = {Philadelphia, Pa. [u.a.]},
      publisher    = {Saunders},
      reportid     = {DKFZ-2021-03172},
      pages        = {1088-1097.e3},
      year         = {2022},
      note         = {#EA:C070#LA:C070#LA:C120# / Volume 162, Issue 4, April
                      2022, Pages 1088-1097.e3},
      abstract     = {Incidence of colorectal cancer (CRC) in younger adults is
                      increasing in many countries. Given the established
                      association of body mass index (BMI) with CRC risk and the
                      increasing obesity prevalence among younger generations, we
                      aimed to evaluate the association of BMI at different ages
                      during early adulthood with early-onset CRC.Among 6602 CRC
                      patients and 7950 matched controls who were recruited in
                      2003-2020 in the DACHS study, a population-based
                      case-control study from Germany, 747 patients and 621
                      controls were below age 55 and included in this analysis.
                      Self-reported height and weight at ages 20 and 30 years, and
                      at approximately 10 years before diagnosis or interview were
                      recorded in personal interviews. Associations of BMI with
                      early-onset CRC were estimated using multiple logistic
                      regression.Compared to participants with BMI <25 kg/m2,
                      those with BMI ≥30 kg/m2 (obesity) at age 20 and 30 years
                      and approximately 10 years before diagnosis/interview had
                      2.56 $(95\%$ CI 1.20-5.44), 2.06 (1.25-3.40), and 1.88
                      (1.30-2.73) fold risk of early-onset CRC. The association of
                      BMI with early-onset CRC risk was particularly pronounced
                      among and essentially restricted to the majority of
                      participants with no previous colonoscopy.Obesity at early
                      adulthood is strongly associated with increased risk of
                      early- onset CRC.},
      keywords     = {body mass index (Other) / colorectal cancer (Other) /
                      early-onset colorectal cancer (Other) / obesity (Other)},
      cin          = {C070 / C020 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34914944},
      doi          = {10.1053/j.gastro.2021.12.239},
      url          = {https://inrepo02.dkfz.de/record/178167},
}