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000178293 0247_ $$2doi$$a10.17116/neiro20218506198
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000178293 037__ $$aDKFZ-2021-03240
000178293 041__ $$aRussian
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000178293 1001_ $$aRyzhova, M. V.$$b0
000178293 245__ $$aSovremennye diagnosticheskie vozmozhnosti molekulyarnogo issledovaniya opukholei mozga v Tsentre neirokhirurgii im. akad. N.N. Burdenko.
000178293 260__ $$aMoskva$$bNakl. Medicina$$c2021
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000178293 520__ $$aDnA methylation has recently been accepted as the most reliable and effective method of diagnosing central nervous system (CNS) tumors. Healthy organs and tumors of different localizations have their own unique methylation structure. Determination of total tumor DNA methylome is the detection of all methylated nucleotides in a tumor. The 'gold standard' for analyzing the methylation state of individual cytosines is bisulfite conversion, in which unmethylated cytosines are converted to uracils and read as thymines, while methylated cytosines are protected from conversion.
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000178293 650_7 $$2Other$$aDNA methylation
000178293 650_7 $$2Other$$aEPIC array
000178293 650_7 $$2Other$$aIllumina Infinium HumanMethylation850 BeadChip
000178293 650_7 $$09007-49-2$$2NLM Chemicals$$aDNA
000178293 650_2 $$2MeSH$$aBrain Neoplasms: genetics
000178293 650_2 $$2MeSH$$aDNA: metabolism
000178293 650_2 $$2MeSH$$aDNA Methylation
000178293 650_2 $$2MeSH$$aHumans
000178293 7001_ $$aTelysheva, E. N.$$b1
000178293 7001_ $$00000-0002-7882-2579$$aShaikhaev, E. G.$$b2
000178293 7001_ $$00000-0002-1879-393X$$aStarovoitov, D. V.$$b3
000178293 7001_ $$aKotelnikova, A. O.$$b4
000178293 7001_ $$00000-0001-9953-6654$$aGalstyan, S. A.$$b5
000178293 7001_ $$0P:(DE-He78)34b3639de467b2c700920d7cbc3d2110$$aOkonechnikov, Konstantin$$b6$$eLast author$$udkfz
000178293 773__ $$0PERI:(DE-600)603458-5$$a10.17116/neiro20218506198$$gVol. 85, no. 6, p. 98 -$$n6$$p98$$tZurnal voprosy nejrochirurgii imeni N.N. Burdenko$$v85$$x0042-8817$$y2021
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000178293 9141_ $$y2021
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