Journal Article

DKFZ-2021-03240

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sovremennye diagnosticheskie vozmozhnosti molekulyarnogo issledovaniya opukholei mozga v Tsentre neirokhirurgii im. akad. N.N. Burdenko.

Ryzhova, M. V. ; Telysheva, E. N. ; Shaikhaev, E. G. ; Starovoitov, D. V. ; Kotelnikova, A. O. ; Galstyan, S. A. ; Okonechnikov, K. (Last author)DKFZ*

2021
Nakl. Medicina Moskva

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Please use a persistent id in citations: doi:10.17116/neiro20218506198

Abstract: DnA methylation has recently been accepted as the most reliable and effective method of diagnosing central nervous system (CNS) tumors. Healthy organs and tumors of different localizations have their own unique methylation structure. Determination of total tumor DNA methylome is the detection of all methylated nucleotides in a tumor. The 'gold standard' for analyzing the methylation state of individual cytosines is bisulfite conversion, in which unmethylated cytosines are converted to uracils and read as thymines, while methylated cytosines are protected from conversion.

Keyword(s): Brain Neoplasms: genetics (MeSH) ; DNA: metabolism (MeSH) ; DNA Methylation (MeSH) ; Humans (MeSH) ; DNA methylation ; EPIC array ; Illumina Infinium HumanMethylation850 BeadChip ; DNA

Note: #LA:B062#

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Contributing Institute(s):

1. B062 Pädiatrische Neuroonkologie (B062)

Research Program(s):

1. 312 - Funktionelle und strukturelle Genomforschung (POF4-312) (POF4-312)

Appears in the scientific report 2021

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Database coverage:
; SCOPUS

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