TY  - JOUR
AU  - Ryzhova, M. V.
AU  - Telysheva, E. N.
AU  - Shaikhaev, E. G.
AU  - Starovoitov, D. V.
AU  - Kotelnikova, A. O.
AU  - Galstyan, S. A.
AU  - Okonechnikov, Konstantin
TI  - Sovremennye diagnosticheskie vozmozhnosti molekulyarnogo issledovaniya opukholei mozga v Tsentre neirokhirurgii im. akad. N.N. Burdenko.
JO  - Zurnal voprosy nejrochirurgii imeni N.N. Burdenko
VL  - 85
IS  - 6
SN  - 0042-8817
CY  - Moskva
PB  - Nakl. Medicina
M1  - DKFZ-2021-03240
SP  - 98
PY  - 2021
N1  - #LA:B062#
AB  - DnA methylation has recently been accepted as the most reliable and effective method of diagnosing central nervous system (CNS) tumors. Healthy organs and tumors of different localizations have their own unique methylation structure. Determination of total tumor DNA methylome is the detection of all methylated nucleotides in a tumor. The 'gold standard' for analyzing the methylation state of individual cytosines is bisulfite conversion, in which unmethylated cytosines are converted to uracils and read as thymines, while methylated cytosines are protected from conversion.
KW  - Brain Neoplasms: genetics
KW  - DNA: metabolism
KW  - DNA Methylation
KW  - Humans
KW  - DNA methylation (Other)
KW  - EPIC array (Other)
KW  - Illumina Infinium HumanMethylation850 BeadChip (Other)
KW  - DNA (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:34951766
DO  - DOI:10.17116/neiro20218506198
UR  - https://inrepo02.dkfz.de/record/178293
ER  -